Amiloride and Cyclosporine Interaction
Drug interaction information between Amiloride and Cyclosporine.
Amiloride and Cyclosporine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiloride and Cyclosporine. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medications can cause potassium levels in your blood to rise. Taking them together increases the risk of having too much potassium, which can be dangerous.
What To Do
Your doctor should monitor your blood potassium levels closely while you are taking both drugs.
FDA Label Information
Drug Interactions When amiloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, the risk of hyperkalemia may be increased.
Amiloride Also Interacts With
- Potassium Chloride major
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
- Perindopril moderate
Cyclosporine Also Interacts With
- Clarithromycin major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Pitavastatin major
- Simvastatin major
Frequently Asked Questions
Can I take Amiloride and Cyclosporine together?
This is a moderate interaction. Your doctor should monitor your blood potassium levels closely while you are taking both drugs.
How serious is the interaction between Amiloride and Cyclosporine?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Amiloride and Cyclosporine interact?
Both of these medications can cause potassium levels in your blood to rise. Taking them together increases the risk of having too much potassium, which can be dangerous.
Understanding the Amiloride and Cyclosporine Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Amiloride belongs to the Potassium-Sparing Diuretic class and Cyclosporine belongs to the Calcineurin Inhibitor (Immunosuppressant) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medications can cause potassium levels in your blood to rise. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Amiloride has 19 total documented interactions on file in this dataset, and Cyclosporine has 89. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your blood potassium levels closely while you are taking both drugs. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Amiloride or Cyclosporine based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.