Amiloride and Benazepril Interaction
Drug interaction information between Amiloride and Benazepril.
Amiloride and Benazepril have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiloride and Benazepril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two drugs both prevent the kidneys from flushing out potassium. Taking them together increases the risk that your potassium levels will become too high.
FDA Label Information
Hyperkalemia Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) can increase the risk of hyperkalemia.
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Perindopril moderate
Benazepril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Amlodipine/Benazepril minor
Frequently Asked Questions
What SPL severity band is on file for Amiloride + Benazepril?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Benazepril's 5. In the moderate band specifically: Amiloride has 7 (also Cyclosporine, Lithium, Amlodipine/Benazepril, Perindopril); Benazepril has 3 (also Spironolactone, Lithium).
What mechanism field is on file for Amiloride and Benazepril?
These two drugs both prevent the kidneys from flushing out potassium. Taking them together increases the risk that your potassium levels will become too high.
Amiloride's labeled portfolio outnumbers Benazepril
SPL source-record counts only. This page's band is moderate · classes on file: Amiloride (Potassium-Sparing Diuretic); Benazepril (ACE Inhibitor).
1 major · 7 moderate · 11 minor · 19 total
- Other moderate peers for Amiloride
- Cyclosporine
- Lithium
- Amlodipine/Benazepril
- Perindopril
1 major · 3 moderate · 1 minor · 5 total
- Other moderate peers for Benazepril
- Spironolactone
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.