Amiloride and Benazepril Interaction
Drug interaction information between Amiloride and Benazepril.
Amiloride and Benazepril have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Amiloride and Benazepril. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These two drugs both prevent the kidneys from flushing out potassium. Taking them together increases the risk that your potassium levels will become too high.
What To Do
You should have regular blood tests to check your potassium levels if you are prescribed both medications.
FDA Label Information
Hyperkalemia Potassium-sparing diuretics (spironolactone, amiloride, triamterene, and others) can increase the risk of hyperkalemia.
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Perindopril moderate
Benazepril Also Interacts With
- Aliskiren major
- Spironolactone moderate
- Lithium moderate
- Amlodipine/Benazepril minor
Frequently Asked Questions
Can I take Amiloride and Benazepril together?
This is a moderate interaction. You should have regular blood tests to check your potassium levels if you are prescribed both medications.
How serious is the interaction between Amiloride and Benazepril?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Amiloride and Benazepril interact?
These two drugs both prevent the kidneys from flushing out potassium. Taking them together increases the risk that your potassium levels will become too high.
Understanding the Amiloride and Benazepril Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Amiloride belongs to the Potassium-Sparing Diuretic class and Benazepril belongs to the ACE Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These two drugs both prevent the kidneys from flushing out potassium. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Amiloride has 19 total documented interactions on file in this dataset, and Benazepril has 5. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You should have regular blood tests to check your potassium levels if you are prescribed both medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Amiloride or Benazepril based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.