Alogliptin and Cimetidine Interaction
Drug interaction information between Alogliptin and Cimetidine.
Alogliptin and Cimetidine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Alogliptin and Cimetidine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Cimetidine can slow down how the body removes the medication, which may lead to the drug building up in your system.
FDA Label Information
( 7 ) Drugs that reduce metformin clearance (such as ranolazine, vandetanib, dolutegravir, and cimetidine), may increase the accumulation of metformin. Examples: Ranolazine, vandetanib, dolutegravir, and cimetidine Alcohol Clinical Impact: Alcohol is known to potentiate the effect of metformin on lactate metabolism.
Alogliptin Also Interacts With
- Topiramate moderate
- Zonisamide moderate
- Metformin minor
- Dolutegravir minor
- Ranolazine minor
Cimetidine Also Interacts With
- Levofloxacin major
- Posaconazole major
- Risperidone major
- Valproate major
- Empagliflozin moderate
Frequently Asked Questions
What SPL severity band is on file for Alogliptin + Cimetidine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cimetidine has 77 labeled pairs on file vs Alogliptin's 7. In the minor band specifically: Alogliptin has 5 (also Metformin, Dolutegravir, Ranolazine, Phenytoin); Cimetidine has 63 (also Albendazole, Alosetron, Alprazolam, Amiodarone).
What mechanism field is on file for Alogliptin and Cimetidine?
Cimetidine can slow down how the body removes the medication, which may lead to the drug building up in your system.
Cimetidine carries more major-labeled pairs than Alogliptin
SPL source-record counts only. This page's band is minor · classes on file: Alogliptin (DPP-4 Inhibitor); Cimetidine (H2 Receptor Antagonist).
Cimetidine has 4 major-labeled pairs vs Alogliptin's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 5 minor · 7 total
- Other minor peers for Alogliptin
- Metformin
- Dolutegravir
- Ranolazine
- Phenytoin
4 major · 10 moderate · 63 minor · 77 total
- Other minor peers for Cimetidine
- Albendazole
- Alosetron
- Alprazolam
- Amiodarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.