Aliskiren and Itraconazole Interaction
Drug interaction information between Aliskiren and Itraconazole.
Aliskiren and Itraconazole have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aliskiren and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole stops the enzymes that normally remove aliskiren from your system. This makes the blood pressure medicine stay in your body longer than it should.
FDA Label Information
Aliskiren a Riociguat Sildenafil (for pulmonary hypertension) Tadalafil (for pulmonary hypertension) Not recommended during and 2 weeks after itraconazole treatment.
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Aliskiren + Itraconazole?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Aliskiren's 28. In the moderate band specifically: Aliskiren has 3 (also Cyclosporine, Nirmatrelvir/Ritonavir); Itraconazole has 20 (also Tamsulosin, Rivaroxaban, Tenofovir Disoproxil, Glecaprevir/Pibrentasvir).
What mechanism field is on file for Aliskiren and Itraconazole?
Itraconazole stops the enzymes that normally remove aliskiren from your system. This makes the blood pressure medicine stay in your body longer than it should.
Aliskiren carries more major-labeled pairs than Itraconazole
SPL source-record counts only. This page's band is moderate · classes on file: Aliskiren (Direct Renin Inhibitor); Itraconazole (Azole Antifungal).
Aliskiren has 22 major-labeled pairs vs Itraconazole's 19. This page itself is in the moderate band, not the major band.
22 major · 3 moderate · 3 minor · 28 total
- Other moderate peers for Aliskiren
- Cyclosporine
- Nirmatrelvir/Ritonavir
19 major · 20 moderate · 77 minor · 116 total
- Other moderate peers for Itraconazole
- Tamsulosin
- Rivaroxaban
- Tenofovir Disoproxil
- Glecaprevir/Pibrentasvir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.