Aliskiren and Amlodipine/Valsartan Interaction
Drug interaction information between Aliskiren and Amlodipine/Valsartan.
Aliskiren and Amlodipine/Valsartan have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Aliskiren and Amlodipine/Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these two medicines together can over-block the system that regulates blood pressure and kidney health. This can lead to dangerously low blood pressure, high potassium, or sudden kidney failure.
FDA Label Information
Dual Blockade of the Renin-Angiotensin System (RAS): Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with valsartan in patients with diabetes. Avoid use of aliskiren with valsartan in patients with renal impairment (GFR < 60 mL/min).
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Azilsartan major
- Benazepril major
- Candesartan major
- Enalapril major
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
- Hydrochlorothiazide minor
Frequently Asked Questions
What SPL severity band is on file for Aliskiren + Amlodipine/Valsartan?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Amlodipine/Valsartan's 14. In the major band specifically: Aliskiren has 22 (also Amlodipine/Benazepril, Azilsartan, Benazepril, Candesartan); Amlodipine/Valsartan has 2 (also Simvastatin).
What mechanism field is on file for Aliskiren and Amlodipine/Valsartan?
Using these two medicines together can over-block the system that regulates blood pressure and kidney health. This can lead to dangerously low blood pressure, high potassium, or sudden kidney failure.
Aliskiren carries more major-labeled pairs than Amlodipine/Valsartan
SPL source-record counts only. This page's band is major · classes on file: Aliskiren (Direct Renin Inhibitor); Amlodipine/Valsartan (CCB / ARB Combination).
Aliskiren has 22 major-labeled pairs vs Amlodipine/Valsartan's 2.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Benazepril
- Azilsartan
- Benazepril
- Candesartan
2 major · 2 moderate · 10 minor · 14 total
- Other major peers for Amlodipine/Valsartan
- Simvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.