Aliskiren and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Aliskiren and Nirmatrelvir/Ritonavir.
Aliskiren and Nirmatrelvir/Ritonavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Aliskiren and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This combination stops your body from breaking down aliskiren properly, leading to much higher amounts of the drug in your system.
FDA Label Information
Cardiovascular agents aliskiren, ticagrelor, vorapaxar clopidogrel ↑ aliskiren ↑ ticagrelor ↑ vorapaxar ↓ clopidogrel active metabolite Avoid concomitant use with PAXLOVID.
Aliskiren Also Interacts With
- Amlodipine/Benazepril major
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Aliskiren + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Aliskiren's 28. In the moderate band specifically: Aliskiren has 3 (also Cyclosporine, Itraconazole); Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Fluticasone, Apixaban).
What mechanism field is on file for Aliskiren and Nirmatrelvir/Ritonavir?
This combination stops your body from breaking down aliskiren properly, leading to much higher amounts of the drug in your system.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Aliskiren
SPL source-record counts only. This page's band is moderate · classes on file: Aliskiren (Direct Renin Inhibitor); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Aliskiren's 22. This page itself is in the moderate band, not the major band.
22 major · 3 moderate · 3 minor · 28 total
- Other moderate peers for Aliskiren
- Cyclosporine
- Itraconazole
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Fluticasone
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.