Aliskiren and Amlodipine/Benazepril Interaction
Drug interaction information between Aliskiren and Amlodipine/Benazepril.
Aliskiren and Amlodipine/Benazepril have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Aliskiren and Amlodipine/Benazepril. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs target the same system that controls blood pressure, which can cause your blood pressure to drop too low. This combination also increases the risk of kidney damage and high potassium levels.
FDA Label Information
Dual Blockade of the Renin-Angiotensin System (RAS): Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not coadminister aliskiren with Lotrel in patients with diabetes. Avoid use of aliskiren with Lotrel in patients with renal impairment [glomerular filtration rate (GFR) < 60 mL/min].
Aliskiren Also Interacts With
- Amlodipine/Valsartan major
- Azilsartan major
- Benazepril major
- Candesartan major
- Enalapril major
Amlodipine/Benazepril Also Interacts With
- Amlodipine major
- Simvastatin major
- Lithium major
- Spironolactone moderate
- Amiloride moderate
Frequently Asked Questions
What SPL severity band is on file for Aliskiren + Amlodipine/Benazepril?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Aliskiren has 28 labeled pairs on file vs Amlodipine/Benazepril's 7. In the major band specifically: Aliskiren has 22 (also Amlodipine/Valsartan, Azilsartan, Benazepril, Candesartan); Amlodipine/Benazepril has 4 (also Amlodipine, Simvastatin, Lithium).
What mechanism field is on file for Aliskiren and Amlodipine/Benazepril?
Both of these drugs target the same system that controls blood pressure, which can cause your blood pressure to drop too low. This combination also increases the risk of kidney damage and high potassium levels.
Aliskiren carries more major-labeled pairs than Amlodipine/Benazepril
SPL source-record counts only. This page's band is major · classes on file: Aliskiren (Direct Renin Inhibitor); Amlodipine/Benazepril (Calcium Channel Blocker / ACE Inhibitor Combination).
Aliskiren has 22 major-labeled pairs vs Amlodipine/Benazepril's 4.
22 major · 3 moderate · 3 minor · 28 total
- Other major peers for Aliskiren
- Amlodipine/Valsartan
- Azilsartan
- Benazepril
- Candesartan
4 major · 2 moderate · 1 minor · 7 total
- Other major peers for Amlodipine/Benazepril
- Amlodipine
- Simvastatin
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.