What the label lists and what reports show

Hydrochlorothiazide and metoprolol side effects

Hydrochlorothiazide and metoprolol's FDA label lists its adverse reactions in its own words. FAERS holds 208 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is nausea (15 reports).

Generic listed

Check it at the source: the hydrochlorothiazide and metoprolol FDA label on DailyMed (effective January 15, 2024, Mylan Pharmaceuticals Inc.); the FDA FAERS public dashboard.

What does the label list?

From the label: adverse reactions
The following adverse reactions are described in more detail elsewhere in the label; • Worsening angina or myocardial infarction [see Warnings and Precautions (5) ] • Worsening heart failure [see Warnings and Precautions (5) ] • Worsening AV block [see Contraindications (4) ] To report SUSPECTED ADVERSE REACTIONS, contact Mylan at 1-877-446-3679 (1-877-4-INFO-RX) or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. 6.2 Post-Marketing Experience The following adverse reactions have been reported in postmarketing experience: adverse reactions have been identified during post approval use of metoprolol tartrate and hydrochlorothiazide tablets. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. …

Source: FDA drug label, Mylan Pharmaceuticals Inc., effective January 15, 2024 (SPL set b6cf0f43-8dc3-4535-b651-daf1f9e0336c), via openFDA; the full label on DailyMed

What do FAERS reports show?

208 reports list hydrochlorothiazide and metoprolol among the medicines taken, each a report of something that happened, not proof the medicine caused it; 31 are coded as a death and 91 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 21 reactions below, 6 are named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.

The 25 most reported reactions

Nausea (named in the label)15
Fatigue13
Death (an outcome recorded in the report)11
Dyspnoea11
Renal Failure Acute11
Diarrhoea (named in the label)10
Anaemia (named in the label)9
Asthenia9
Dizziness (named in the label)9
Drug Interaction (a use or a product term, not a reaction)8
Pain8
Vomiting (named in the label)8
Weight Decreased8
Cough7
Depression7
Off Label Use (a use or a product term, not a reaction)7
Pruritus7
Dehydration6
Drug Ineffective (a use or a product term, not a reaction)6
Eye Irritation6
Fall6
Headache (named in the label)6
Muscle Spasms6
Pleural Effusion6
Abdominal Pain5

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms

What next?

Hydrochlorothiazide and metoprolol: the full record: label, generics, price, shortages, recalls
Report a side effect to the FDA: MedWatch
Side effects hub: the most reported medicines and reactions