Prescription medicine
Hydrochlorothiazide and metoprolol First approved as Lopressor Hct
Hydrochlorothiazide and metoprolol (Lopressor Hct) is a prescription medicine with an FDA approval on record since 1984. FDA's NDC Directory lists it from 5 generic labelers, and pharmacies paid $1.41 per metoprolol-hydrochlorothiazide 100-25 mg tablet in the October 7, 2026 NADAC survey.
- Generic listed
Check it at the source: the hydrochlorothiazide and metoprolol FDA label on DailyMed (effective January 15, 2024, Mylan Pharmaceuticals Inc.); the NDA 18303 record on Drugs@FDA; every hydrochlorothiazide and metoprolol label on DailyMed.
Highlights of the record
FDA label of January 15, 2024; NDC Directory, Drugs@FDA and Orange Book, October 8, 2026; NADAC October 7, 2026
Used for
From the label: indications and usageMetoprolol tartrate and hydrochlorothiazide tablets are indicated for the treatment of hypertension, to lower blood pressure.
Forms and strengths
- 50 mg / 25 mg
- 100 mg / 25 mg
- 100 mg / 50 mg
Tablet.
On the market
- Earliest approval on file
- December 31, 1984 Lopressor Hct, Validus Pharms; Drugs@FDA’s file, where older or withdrawn approvals can be missing
- Generic approvals
- 4 first August 20, 2004; 3 with a marketed status in Drugs@FDA
- Labelers listed (NDC)
- 5 of which 5 under generic applications, 0 under brand applications, repackagers included
Supply and safety
- Pharmacy cost (NADAC)
- $1.41 per tablet Metoprolol-hydrochlorothiazide 100-25 mg tablet
- Shortage (FDA)
- No current entry
- Recalls by its makers (FDA)
- 1 since 2021 0 Class I among all firms' recalls; latest March 15, 2021
- FAERS reports
- 208 through July 30, 2026
What is hydrochlorothiazide and metoprolol used for?
From the label: indications and usageMetoprolol tartrate and hydrochlorothiazide tablets are indicated for the treatment of hypertension, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including metoprolol. Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. […]
Conditions named in the indications of hydrochlorothiazide and metoprolol's FDA labels, with every medicine labeled for each:
FDA pharmacologic class: Thiazide Diuretic and beta-Adrenergic Blocker.
Source: FDA drug label (Metoprolol Tartrate and Hydrochlorothiazide), Mylan Pharmaceuticals Inc., effective January 15, 2024 (SPL set b6cf0f43-8dc3-4535-b651-daf1f9e0336c), via openFDA; the full label on DailyMed
Is there a generic for hydrochlorothiazide and metoprolol (Lopressor Hct)?
The FDA approved the first generic hydrochlorothiazide and metoprolol on August 20, 2004. 4 generic applications are approved; 3 of them carry a current (not discontinued) marketing status in Drugs@FDA; that status is not evidence that the generic is on sale.
FDA's NDC Directory lists hydrochlorothiazide and metoprolol from 5 labelers under a generic (ANDA) application. A listing means the company has registered the product for sale; it does not show that every pharmacy stocks it.
- 1984 earliest approval on file
- 2004 first generic approved
- red ticks recalls
Source: Drugs@FDA, FDA NDC Directory and the Orange Book (openFDA bulk files, October 8, 2026)
What do pharmacies pay for hydrochlorothiazide and metoprolol (Lopressor Hct)?
In CMS's NADAC survey of October 7, 2026, pharmacies paid $1.41 per Metoprolol-hydrochlorothiazide 100-25 mg tablet, up 12% from $1.26 on October 8, 2025. The chart's scale runs from the lowest to the highest price shown, not from zero. NADAC is what retail pharmacies paid their wholesalers, per unit, in CMS's monthly survey; what a patient pays depends on insurance and the pharmacy.
- Metoprolol-hydrochlorothiazide 50-25 mg tablet (generic)
| Strength and form | Brand or generic | Pharmacy cost | 30 tablets, or one pen or vial | 12-month change |
|---|---|---|---|---|
| Metoprolol-hydrochlorothiazide 100-25 mg tablet | Generic | $1.41 per tablet | $42.33 | +12% |
| Metoprolol-hydrochlorothiazide 100-50 mg tablet | Generic | $1.36 per tablet | $40.79 | n/a |
| Metoprolol-hydrochlorothiazide 50-25 mg tablet | Generic | $0.909 per tablet | $27.28 | -4% |
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
Has hydrochlorothiazide and metoprolol been recalled?
The FDA's Enforcement Report lists 1 recall naming hydrochlorothiazide and metoprolol since 2021: 0 Class I (the most serious), 1 Class II, 0 Class III; 0 still ongoing. A recall names products and lots, not every product of the medicine.
| Started | Class | Company | Reason |
|---|---|---|---|
| March 15, 2021 | Class II | Cardinal Health Inc. | CGMP Deviations: Intermittent exposure to temperature excursion during storage. |
Source: FDA Enforcement Report (drug recalls) via openFDA, through October 8, 2026
What does the hydrochlorothiazide and metoprolol label say about other medicines?
The hydrochlorothiazide and metoprolol label names 11 other medicines in its interaction, contraindication or warning sections. The sentences are the labels' own; a label lists what its studies and reports found, not every interaction.
| Medicine named | Section | What the label says |
|---|---|---|
| Cholestyramine | drug interactions | Cholestyramine and colestipol: Reduced absorption of thiazides. |
| Clonidine | drug interactions | Digitalis, Clonidine, and Calcium Channel Blockers Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. |
| Colestipol | drug interactions | Cholestyramine and colestipol: Reduced absorption of thiazides. |
| Diltiazem | drug interactions | Digitalis, Clonidine, and Calcium Channel Blockers Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. |
| Epinephrine | warnings and precautions | Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. |
| Fluoxetine | drug interactions | CYP2D6 Inhibitors Drugs that are strong inhibitors of CYP2D6 such as quinidine, fluoxetine, paroxetine, and propafenone were shown to double metoprolol concentrations. |
| Lithium | drug interactions | Risk of lithium toxicity. |
| Paroxetine | drug interactions | CYP2D6 Inhibitors Drugs that are strong inhibitors of CYP2D6 such as quinidine, fluoxetine, paroxetine, and propafenone were shown to double metoprolol concentrations. |
| Propafenone | drug interactions | CYP2D6 Inhibitors Drugs that are strong inhibitors of CYP2D6 such as quinidine, fluoxetine, paroxetine, and propafenone were shown to double metoprolol concentrations. |
| Quinidine | drug interactions | CYP2D6 Inhibitors Drugs that are strong inhibitors of CYP2D6 such as quinidine, fluoxetine, paroxetine, and propafenone were shown to double metoprolol concentrations. |
| Verapamil | drug interactions | Digitalis, Clonidine, and Calcium Channel Blockers Digitalis glycosides, clonidine, diltiazem and verapamil slow atrioventricular conduction and decrease heart rate. |
Check hydrochlorothiazide and metoprolol against other medicines
Source: FDA drug label (Metoprolol Tartrate and Hydrochlorothiazide), Mylan Pharmaceuticals Inc., effective January 15, 2024 (SPL set b6cf0f43-8dc3-4535-b651-daf1f9e0336c), via openFDA; the full label on DailyMed
What do FAERS reports show for hydrochlorothiazide and metoprolol?
The FDA Adverse Event Reporting System holds 208 reports that list hydrochlorothiazide and metoprolol among the medicines taken, through July 30, 2026, each a report of something that happened, not proof the medicine caused it; 31 are coded as a death and 91 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is.
The most reported reactions
Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026
What else is labeled for the same conditions as hydrochlorothiazide and metoprolol?
59 other medicines are given the same way (oral) and in the same FDA class as hydrochlorothiazide and metoprolol or labeled mainly for the same use (high blood pressure), the same class first. High blood pressure lists all 88 medicines labeled for it, by any route. The first 8 are below. They are listed as records, not as substitutes: whether one can replace another is a prescriber's decision.
| Medicine | Shared indication | Generic labelers (oral) | Pharmacy cost | Shortage |
|---|---|---|---|---|
| Propranolol | High blood pressure | 38 labelers | $0.0493 per tablet 20 mg tablet | In shortage |
| Carvedilol | High blood pressure | 41 labelers | $0.0179 per tablet 6.25 mg tablet | No current entry |
| Atenolol | High blood pressure | 35 labelers | $0.0217 per tablet 25 mg tablet | No current entry |
| Labetalol | High blood pressure | 31 labelers | $0.215 per tablet 300 mg tablet | No current entry |
| Nebivolol | High blood pressure | 23 labelers | $0.141 per tablet 10 mg tablet | A presentation being discontinued |
| Nadolol | High blood pressure | 16 labelers | $0.147 per tablet 20 mg tablet | No current entry |
| Bisoprolol | High blood pressure | 24 labelers | $0.114 per tablet 5 mg tablet | No current entry |
| Pindolol | High blood pressure | 8 labelers | $0.854 per tablet 10 mg tablet | A presentation being discontinued |
Every medicine labeled for the same conditions as hydrochlorothiazide and metoprolol
Source: FDA drug labels (indications), NDC Directory, NADAC of October 7, 2026, FDA shortages (October 8, 2026)
What next?
- Alternatives to hydrochlorothiazide and metoprolol
- 59 medicines for the same use
- Other thiazide diuretics
- the pharmacologic class, with prices and generics
- Hydrochlorothiazide and metoprolol side effects
- the label's list beside FAERS reports
- Check an interaction
- what two or more labels say about each other