Medicines labeled for the same conditions
Alternatives to hydrochlorothiazide and spironolactone
27 other medicines are given the same way (oral) and in the same FDA class as hydrochlorothiazide and spironolactone or labeled mainly for the same use (heart failure); 2 are in its class, aldosterone antagonists: eplerenone and chlorothiazide; the others include 5 angiotensin converting enzyme inhibitors, 4 loop diuretics and 3 thiazide-like diuretics (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.308 per eplerenone 25 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as hydrochlorothiazide and spironolactone?
The first 24 of the 27, the same class first. Heart failure lists all 37 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Hydrochlorothiazide and spironolactonealdosterone antagonist | this medicine | 6 labelers | $0.483 per tablet 25-25 tablet | No | No current entry |
| Eplerenonealdosterone antagonist · same class | High blood pressure, Heart failure | 9 labelers | $0.308 per tablet 25 mg tablet | No | No current entry |
| Chlorothiazidethiazide diuretic · same class | High blood pressure, Heart failure, Edema (fluid retention) | none listed | n/a | No | A presentation being discontinued |
| Metoprololbeta-adrenergic blocker | High blood pressure, Heart failure | 64 labelers | $0.085 per tablet 100 mg tablet | No | A presentation being discontinued |
| Lisinoprilangiotensin converting enzyme inhibitor | High blood pressure, Heart failure | 36 labelers | $0.0254 per tablet 20 mg tablet | Yes | No current entry |
| Carvedilolalpha-adrenergic blocker | High blood pressure, Heart failure | 41 labelers | $0.0179 per tablet 6.25 mg tablet | No | No current entry |
| Valsartanangiotensin 2 receptor blocker | High blood pressure, Heart failure | 34 labelers | $0.0963 per tablet 40 mg tablet | Yes | A presentation being discontinued |
| Furosemideloop diuretic | High blood pressure, Heart failure | 33 labelers | $0.026 per tablet 20 mg tablet | No | In shortage |
| Enalaprilangiotensin converting enzyme inhibitor | High blood pressure, Heart failure | 29 labelers | $0.0664 per tablet 10 mg tablet | Yes | No current entry |
| Chlorthalidonethiazide-like diuretic | High blood pressure, Heart failure, Edema (fluid retention) | 36 labelers | $0.0743 per tablet 25 mg tablet | No | No current entry |
| Sacubitril and valsartanneprilysin inhibitor | Heart failure | 27 labelers | $0.533 per unit 49-51 mg | Yes | No current entry |
| Bumetanideloop diuretic | Heart failure | 24 labelers | $0.108 per tablet 1 mg tablet | Yes | Resolved |
| Metolazonethiazide-like diuretic | High blood pressure, Heart failure, Edema (fluid retention) | 19 labelers | $0.233 per tablet 2.5 mg tablet | No | No current entry |
| Torsemideloop diuretic | High blood pressure, Heart failure | 20 labelers | $0.0636 per tablet 20 mg tablet | No | No current entry |
| Captoprilangiotensin converting enzyme inhibitor | High blood pressure, Heart failure | 13 labelers | $0.228 per tablet 12.5 mg tablet | Yes | No current entry |
| Digoxincardiac glycoside | Heart failure | 21 labelers | $0.133 per tablet 125 mcg tablet | No | No current entry |
| Candesartanangiotensin 2 receptor blocker | High blood pressure, Heart failure | 8 labelers | $0.478 per tablet 16 mg tablet | Yes | No current entry |
| Quinaprilangiotensin converting enzyme inhibitor | High blood pressure, Heart failure | 9 labelers | n/a | Yes | In shortage |
| Ivabradinehyperpolarization-activated cyclic nucleotide-gated channel blocker | Heart failure | 11 labelers | $0.761 per tablet 5 mg tablet | No | A presentation being discontinued |
| Fosinoprilangiotensin converting enzyme inhibitor | High blood pressure, Heart failure | 7 labelers | $0.154 per tablet 10 mg tablet | Yes | No current entry |
| Indapamidethiazide-like diuretic | High blood pressure, Heart failure, Edema (fluid retention) | 8 labelers | $0.109 per tablet 1.25 mg tablet | No | No current entry |
| Empagliflozinsodium-glucose cotransporter 2 inhibitor | Heart failure | none listed | $11.19 per tablet 10 mg tablet | No | No current entry |
| Ethacrynic acidloop diuretic | Heart failure, Edema (fluid retention) | 8 labelers | $0.807 per tablet 25 mg tablet | No | No current entry |
| Triamterenepotassium-sparing diuretic | Heart failure, Edema (fluid retention) | 3 labelers | $5.98 per capsule 50 mg capsule | Yes | No current entry |
| Hydralazine and isosorbide dinitratearteriolar vasodilator | Heart failure | 3 labelers | $0.714 per tablet 20-37.5 mg tablet | No | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Hydrochlorothiazide and spironolactone: the full record
- label, generics, price, shortages, recalls