Prescription medication · HCN Channel Blocker
ivabradine
Also sold as Corlanor. Ivabradine is used to lower the chance of hospitalization if your heart failure gets worse.
Data updated 2026-05-15
- 6,539
- FDA reportsLightly reported
- 10
- InteractionsSeveral interactions
- 57% less
- Generic vs brandBig savings
- $9.53
- Brand price (NADAC)
What the data shows
ivabradine (Corlanor) is a prescription HCN Channel Blocker, reported less often than most tracked drugs (6,539 FDA reports), whose generic runs roughly half the brand price or less (57% less).
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
ivabradine (Corlanor) is a prescription HCN Channel Blocker. Ivabradine is used to lower the chance of hospitalization if your heart failure gets worse.
Ivabradine (Corlanor) is a medicine that helps lower the risk of needing to go to the hospital for worsening heart failure. It works by slowing down your heart rate.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$9.53/unit
Generic Price
$4.12/unit
Generic Savings
57%
Generic Available
Yes (6 manufacturers)
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Ivabradine is used to lower the chance of hospitalization if your heart failure gets worse.
Common side effects
Slow heart rate, High blood pressure, Irregular heartbeat (atrial fibrillation)
Key warnings
Ivabradine can harm an unborn baby.
The sections below are summarized in plain English from ivabradine's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
Ivabradine works by blocking certain channels in your heart called HCN channels. These channels control your heart's natural pacemaker. By blocking these channels, ivabradine slows down your heart rate.
Side Effects (from patient reports)
Based on 6,539 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for ivabradine, by number of reports
- Dyspnoea
Dyspnoea
460 reports
- Hypotension
Hypotension
413 reports
- Dizziness
Dizziness
350 reports
- Cardiac Failure
Cardiac Failure
324 reports
- Fatigue
Fatigue
317 reports
- Drug Interaction
Drug Interaction
308 reports
- Nausea
Nausea
253 reports
- Bradycardia
Bradycardia
248 reports
- Headache
Headache
231 reports
- Chest Pain
Chest Pain
195 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for ivabradine each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where ivabradine sits
ivabradine has more FDA adverse-event reports than 30% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is ivabradine; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 6,539 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2007–2025.
Total Reports
6,539
Reports Mentioning Death
494
7.6% of reports — not proof of cause
Hospitalization Reports
2,361
Top Indication
Product Used For Unknown Indication
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 2 | DYSPNOEA | 460 |
| 3 | HYPOTENSION | 413 |
| 4 | DIZZINESS | 350 |
| 5 | CARDIAC FAILURE | 324 |
| 6 | FATIGUE | 317 |
| 7 | DRUG INTERACTION | 308 |
| 9 | NAUSEA | 253 |
| 10 | BRADYCARDIA | 248 |
| 11 | HEADACHE | 231 |
| 12 | CHEST PAIN | 195 |
| 13 | MALAISE | 185 |
| 14 | PALPITATIONS | 174 |
| 15 | ASTHENIA | 162 |
| 16 | SYNCOPE | 156 |
| 17 | DIARRHOEA | 153 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Serious Warnings
Ivabradine can harm an unborn baby. If you are a woman who could get pregnant, use effective birth control while taking this medicine. This medicine can also cause a very slow heart rate. Your doctor will monitor your heart rate and adjust your dose as needed.
Known Drug Interactions
Cardiac Disorders : ranolazine, ivabradine ↑ ranolazine ↑ ivabradine Co-administration is contraindicated due to potential for serious and/or life-threatening reactions.
Mechanism: Darunavir prevents your body from clearing ivabradine, which causes the drug to build up to unsafe levels. This increase can lead to severe or life-threatening reactions.
Cardiovascular Drugs, Miscellaneous Ivabradine Ranolazine Contraindicated during and 2 weeks after itraconazole treatment.
Mechanism: Itraconazole stops your body from processing ivabradine, which can lead to a risky buildup of the heart medication.
ivabradine ↑ ivabradine Co-administration with ivabradine is contraindicated due to potential for bradycardia or conduction disturbances [see Contraindications (4) ] .
Mechanism: Ritonavir blocks the breakdown of ivabradine, which makes the drug build up in your body. This can cause your heart to beat too slowly or skip beats.
Pimozide, Quinidine, Ivabradine (CYP3A4 Inhibition) Not Studied In Vivo or In Vitro , but Drug Plasma Exposure Likely to be Increased Contraindicated because of potential for QT prolongation and rare occurrence of torsade de pointes.
Mechanism: Voriconazole stops the body from breaking down ivabradine, which can lead to dangerously high levels of the drug in the blood. This increase can cause serious and potentially life-threatening heart rhythm problems.
Hyperpolarization-activated cyclic nucleotide-gated channel blocker Ivabradine Can increase the risk of bradycardia.
Mechanism: Both of these medications work to slow down the heart. When taken together, they can cause the heart rate to drop to a level that is too slow.
This is a plain-language summary of FDA-label interaction records and does not provide individual medication-combination directions.
Common Questions
What should I do if I feel dizzy while taking ivabradine?
Can I drink grapefruit juice while taking ivabradine?
Will ivabradine cure my heart failure?
Can I stop taking ivabradine on my own?
Does ivabradine affect my blood pressure?
Can I take other heart medications with ivabradine?
What if my heart rate goes too low?
How often will my doctor check my heart rate?
Can ivabradine cause vision problems?
Are there any foods I should avoid while taking ivabradine?
What are the common side effects of ivabradine?
Does ivabradine interact with other medications?
What drug class is ivabradine?
Is there a generic version of ivabradine?
What pregnancy or breastfeeding source fields are listed for ivabradine?
Related Medications in HCN Channel Blocker
Other drugs grouped near ivabradine - same-class peers and common alternatives.
adenosine
Adenocard
Adenosine (Adenocard) is a medicine used to treat certain types of irregular heartbeats.
Compare with ivabradine →
amiodarone
Cordarone, Pacerone
Amiodarone (Pacerone) is a medicine used to treat life-threatening, irregular heartbeats.
Compare with ivabradine →
atropine
AtroPen
Atropine is a medicine that can temporarily block severe effects on your body.
Compare with ivabradine →
bumetanide
Bumex
Bumetanide is a water pill (diuretic).
Compare with ivabradine →
carvedilol
Coreg
Carvedilol is a medicine that lowers blood pressure and helps your heart work better.
Compare with ivabradine →
Compare beyond drug class
Nationwide peers by FAERS volume & death-report share
Two PlainMeds-derived comparison paths for ivabradine: nearest FDA FAERS report volume and nearest death-report share among drugs with at least 1,000 logged reports, excluding same-class neighbors listed above. Counts reflect reporting volume, not proven individual harm.
Similar FAERS report volume
Nearest drugs by total FAERS reports. This record: 6,539.
Similar death-report share
Nearest drugs by FAERS death-report share. This record: 7.55%.
- amitriptyline Δ 0.03 pts · 16,403 reports · Tricyclic Antidepressant (TCA) 7.53%death share
- mepolizumab Δ 0.03 pts · 47,215 reports · Anti-IL-5 Monoclonal Antibody 7.52%death share
- felodipine Δ 0.07 pts · 11,019 reports · Calcium Channel Blocker 7.62%death share
- irbesartan Δ 0.07 pts · 43,004 reports · Angiotensin II Receptor Blocker (ARB) 7.48%death share
Medication Guides
Understanding Drug Interactions
How CYP450 enzymes, inhibitors, and inducers affect your medications
Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
FDA bioequivalence and label-record context for narrow therapeutic index medicines
Common Drug Interactions
Dangerous medication combinations and how to protect yourself
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What the FDA Data Shows for ivabradine
The FDA label for ivabradine (sold under brand names such as Corlanor) classifies it as a prescription-only medication in the HCN Channel Blocker class. Ivabradine is used to lower the chance of hospitalization if your heart failure gets worse. Official labeling lists 4 commonly reported side effects, including Slow heart rate, High blood pressure, Irregular heartbeat (atrial fibrillation).
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 6,539 voluntary reports. The database also lists 10 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated major severity. NADAC pricing from CMS shows a generic unit cost of $4.12 versus $9.53 for the brand - a 57% generic savings.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information are separate source-record fields. This page is a public FDA/CMS registry and does not provide medical, treatment, substitution, or medication-change directions.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. This registry does not provide medication decisions.
Last updated: April 15, 2025
PlainMeds is rendered directly from FDA openFDA/FAERS extracts, DailyMed labels, and CMS drug-pricing files, no number is typed in by an editor. FAERS counts, recalls, shortages, and price figures on this page are queried live from those federal extracts. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error. Data current as of 2026-05-15. Primary sources: openFDA / FAERS, DailyMed and CMS Part B ASP.
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled from the source snapshot dated . See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a data issue.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages