What the FDA labels say about taking them together
Deutetrabenazine and tetrabenazine
Deutetrabenazine's FDA label of February 28, 2025 names tetrabenazine in its contraindications section, and tetrabenazine's label names deutetrabenazine too. The deutetrabenazine label: “Tetrabenazine or Valbenazine AUSTEDO XR and AUSTEDO are contraindicated in patients currently taking tetrabenazine or valbenazine.”
Check it at the source: the deutetrabenazine FDA label on DailyMed (effective February 28, 2025, Teva Neuroscience, Inc.); the tetrabenazine FDA label on DailyMed (effective November 29, 2019, Oceanside Pharmaceuticals).
What does the deutetrabenazine label say about tetrabenazine?
Deutetrabenazine label, contraindicationsTaking tetrabenazine or valbenazine [see Drug Interactions ( 7.6 )].
Deutetrabenazine label, drug interactionsTetrabenazine or Valbenazine AUSTEDO XR and AUSTEDO are contraindicated in patients currently taking tetrabenazine or valbenazine.
Deutetrabenazine label, warnings and precautionsWhile NMS has not been observed in patients receiving AUSTEDO XR or AUSTEDO, it has been observed in patients receiving tetrabenazine (a closely related VMAT2 inhibitor).
Source: FDA drug label (Austedo), Teva Neuroscience, Inc., effective February 28, 2025 (SPL set 7ea3c60a-45c7-44cc-afc2-d87fa53993c0), via openFDA; the full label on DailyMed
What does the tetrabenazine label say about deutetrabenazine?
Tetrabenazine label, contraindicationsTaking monoamine oxidase inhibitors (MAOIs) or reserpine Taking deutetrabenazine or valbenazine
Tetrabenazine label, drug interactionsDeutetrabenazine or Valbenazine Tetrabenazine tablets are contraindicated in patients currently taking deutetrabenazine or valbenazine.
Source: FDA drug label (tetrabenazine), NDA021894 (Bausch), as published by Oceanside Pharmaceuticals, effective November 29, 2019 (SPL set 5867189c-17bd-4e70-a079-c4730f9950d1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Deutetrabenazine | Tetrabenazine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $249.32 per unit 12-18-24-30 mg) | $0.702 per tablet 12.5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once