Tetrabenazine and Haloperidol Interaction
Drug interaction information between Tetrabenazine and Haloperidol.
Tetrabenazine and Haloperidol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tetrabenazine and Haloperidol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these drugs increases the risk of heart rhythm changes and severe movement disorders like Parkinsonism.
FDA Label Information
7.5 Drugs That Cause QTc Prolongation Tetrabenazine causes a small prolongation of QTc (about 8 msec), concomitant use with other drugs that are known to cause QTc prolongation should be avoided, these including antipsychotic medications (e.g., chlorpromazine, haloperidol, thioridazine, ziprasidone), antibiotics (e.g., moxifloxacin), Class 1A (e.g., quinidine, procainamide) and Class III (e.g., amiodarone, sotalol) antiarrhythmic medications or any other medications known to prolong the QTc interval. 7.6 Neuroleptic Drugs The risk for Parkinsonism, NMS, and akathisia may be increased by...
Tetrabenazine Also Interacts With
- Deutetrabenazine major
- Valbenazine major
- Olanzapine moderate
- Risperidone moderate
- Ziprasidone moderate
Haloperidol Also Interacts With
- Fluoxetine moderate
- Bromocriptine minor
- Bupropion minor
- Carbamazepine minor
- Clomipramine minor
Frequently Asked Questions
What SPL severity band is on file for Tetrabenazine + Haloperidol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tetrabenazine has 16 labeled pairs on file vs Haloperidol's 14. In the moderate band specifically: Tetrabenazine has 9 (also Olanzapine, Risperidone, Ziprasidone, Chlorpromazine); Haloperidol has 2 (also Fluoxetine).
What mechanism field is on file for Tetrabenazine and Haloperidol?
Combining these drugs increases the risk of heart rhythm changes and severe movement disorders like Parkinsonism.
Tetrabenazine carries more major-labeled pairs than Haloperidol
SPL source-record counts only. This page's band is moderate · classes on file: Tetrabenazine (VMAT2 Inhibitor); Haloperidol (Typical Antipsychotic).
Tetrabenazine has 2 major-labeled pairs vs Haloperidol's 0. This page itself is in the moderate band, not the major band.
2 major · 9 moderate · 5 minor · 16 total
- Other moderate peers for Tetrabenazine
- Olanzapine
- Risperidone
- Ziprasidone
- Chlorpromazine
0 major · 2 moderate · 12 minor · 14 total
- Other moderate peers for Haloperidol
- Fluoxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.