Tetrabenazine and Risperidone Interaction
Drug interaction information between Tetrabenazine and Risperidone.
Tetrabenazine and Risperidone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Tetrabenazine and Risperidone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both block dopamine, which can lead to movement disorders like tremors or a life-threatening reaction.
FDA Label Information
7.6 Neuroleptic Drugs The risk for Parkinsonism, NMS, and akathisia may be increased by concomitant use of tetrabenazine and dopamine antagonists or antipsychotics (e.g., chlorpromazine, haloperidol, olanzapine, risperidone, thioridazine, ziprasidone) [see Warnings and Precautions ( 5.4 , 5.5 , 5.6 )] .
Tetrabenazine Also Interacts With
- Deutetrabenazine major
- Valbenazine major
- Olanzapine moderate
- Ziprasidone moderate
- Haloperidol moderate
Risperidone Also Interacts With
- Amitriptyline major
- Carbamazepine major
- Lithium major
- Erythromycin major
- Ranitidine major
Frequently Asked Questions
What SPL severity band is on file for Tetrabenazine + Risperidone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Risperidone has 20 labeled pairs on file vs Tetrabenazine's 16. In the moderate band specifically: Tetrabenazine has 9 (also Olanzapine, Ziprasidone, Haloperidol, Chlorpromazine); Risperidone has 5 (also Methylphenidate, Valproate, Digoxin, Dexmethylphenidate).
What mechanism field is on file for Tetrabenazine and Risperidone?
These medications both block dopamine, which can lead to movement disorders like tremors or a life-threatening reaction.
Risperidone carries more major-labeled pairs than Tetrabenazine
SPL source-record counts only. This page's band is moderate · classes on file: Tetrabenazine (VMAT2 Inhibitor); Risperidone (Atypical Antipsychotic).
Risperidone has 6 major-labeled pairs vs Tetrabenazine's 2. This page itself is in the moderate band, not the major band.
2 major · 9 moderate · 5 minor · 16 total
- Other moderate peers for Tetrabenazine
- Olanzapine
- Ziprasidone
- Haloperidol
- Chlorpromazine
6 major · 5 moderate · 9 minor · 20 total
- Other moderate peers for Risperidone
- Methylphenidate
- Valproate
- Digoxin
- Dexmethylphenidate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.