Vortioxetine and Carbamazepine Interaction
Drug interaction information between Vortioxetine and Carbamazepine.
Vortioxetine and Carbamazepine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vortioxetine and Carbamazepine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medications together can interfere with how your blood clots, which increases your risk of bleeding.
FDA Label Information
Examples rifampin, carbamazepine, phenytoin Drugs that Interfere with Hemostasis (antiplatelets agents and anticoagulants) Clinical Impact Concomitant use of TRINTELLIX with an antiplatelet or anticoagulant drug may potentiate the risk of bleeding.
Vortioxetine Also Interacts With
- Linezolid moderate
- Rifampin moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Carbamazepine Also Interacts With
- Nirmatrelvir/Ritonavir major
- Ranolazine major
- Risperidone major
- Lithium moderate
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Vortioxetine + Carbamazepine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Carbamazepine has 129 labeled pairs on file vs Vortioxetine's 18. In the moderate band specifically: Vortioxetine has 7 (also Linezolid, Rifampin, Phenelzine, Tranylcypromine); Carbamazepine has 16 (also Lithium, Apixaban, Desmopressin, Dronedarone).
What mechanism field is on file for Vortioxetine and Carbamazepine?
Taking these medications together can interfere with how your blood clots, which increases your risk of bleeding.
Carbamazepine carries more major-labeled pairs than Vortioxetine
SPL source-record counts only. This page's band is moderate · classes on file: Vortioxetine (Serotonin Modulator); Carbamazepine (Anticonvulsant).
Carbamazepine has 3 major-labeled pairs vs Vortioxetine's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 11 minor · 18 total
- Other moderate peers for Vortioxetine
- Linezolid
- Rifampin
- Phenelzine
- Tranylcypromine
3 major · 16 moderate · 110 minor · 129 total
- Other moderate peers for Carbamazepine
- Lithium
- Apixaban
- Desmopressin
- Dronedarone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.