Vortioxetine and Phenelzine Interaction
Drug interaction information between Vortioxetine and Phenelzine.
Vortioxetine and Phenelzine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vortioxetine and Phenelzine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs increase the level of a brain chemical called serotonin. Having too much serotonin can cause a dangerous condition called serotonin syndrome.
FDA Label Information
[see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.2) ] Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of TRINTELLIX with other serotonergic drugs increases the risk of serotonin syndrome.
Vortioxetine Also Interacts With
- Carbamazepine moderate
- Linezolid moderate
- Rifampin moderate
- Tranylcypromine moderate
- Selegiline moderate
Phenelzine Also Interacts With
- Sertraline moderate
- Fluoxetine moderate
- Citalopram moderate
- Venlafaxine moderate
- Fluvoxamine moderate
Frequently Asked Questions
What SPL severity band is on file for Vortioxetine + Phenelzine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenelzine has 27 labeled pairs on file vs Vortioxetine's 18. In the moderate band specifically: Vortioxetine has 7 (also Carbamazepine, Linezolid, Rifampin, Tranylcypromine); Phenelzine has 11 (also Sertraline, Fluoxetine, Citalopram, Venlafaxine).
What mechanism field is on file for Vortioxetine and Phenelzine?
Both drugs increase the level of a brain chemical called serotonin. Having too much serotonin can cause a dangerous condition called serotonin syndrome.
Phenelzine's labeled portfolio outnumbers Vortioxetine
SPL source-record counts only. This page's band is moderate · classes on file: Vortioxetine (Serotonin Modulator); Phenelzine (Monoamine Oxidase Inhibitor (MAOI)).
0 major · 7 moderate · 11 minor · 18 total
- Other moderate peers for Vortioxetine
- Carbamazepine
- Linezolid
- Rifampin
- Tranylcypromine
0 major · 11 moderate · 16 minor · 27 total
- Other moderate peers for Phenelzine
- Sertraline
- Fluoxetine
- Citalopram
- Venlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.