Vortioxetine and Rifampin Interaction
Drug interaction information between Vortioxetine and Rifampin.
Vortioxetine and Rifampin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vortioxetine and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can interfere with how your blood clots. This increases your risk of experiencing bleeding problems.
FDA Label Information
Examples rifampin, carbamazepine, phenytoin Drugs that Interfere with Hemostasis (antiplatelets agents and anticoagulants) Clinical Impact Concomitant use of TRINTELLIX with an antiplatelet or anticoagulant drug may potentiate the risk of bleeding.
Vortioxetine Also Interacts With
- Carbamazepine moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Vortioxetine + Rifampin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Vortioxetine's 18. In the moderate band specifically: Vortioxetine has 7 (also Carbamazepine, Linezolid, Phenelzine, Tranylcypromine); Rifampin has 26 (also Doxycycline, Probenecid, Theophylline, Apixaban).
What mechanism field is on file for Vortioxetine and Rifampin?
Taking these drugs together can interfere with how your blood clots. This increases your risk of experiencing bleeding problems.
Rifampin carries more major-labeled pairs than Vortioxetine
SPL source-record counts only. This page's band is moderate · classes on file: Vortioxetine (Serotonin Modulator); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Vortioxetine's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 11 minor · 18 total
- Other moderate peers for Vortioxetine
- Carbamazepine
- Linezolid
- Phenelzine
- Tranylcypromine
8 major · 26 moderate · 103 minor · 137 total
- Other moderate peers for Rifampin
- Doxycycline
- Probenecid
- Theophylline
- Apixaban
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.