What the FDA labels say about taking them together
Linezolid and vortioxetine
Vortioxetine's FDA label of March 5, 2025 names linezolid in its contraindications section; the linezolid labels PlainMeds reads (3) do not name vortioxetine. The vortioxetine label: “Starting TRINTELLIX in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of serotonin syndrome.”
Check it at the source: the linezolid FDA label on DailyMed (effective June 19, 2026, Hospira, Inc.); the vortioxetine FDA label on DailyMed (effective March 5, 2025, Takeda Pharmaceuticals America, Inc.).
What does the linezolid label say about vortioxetine?
Linezolid's label (effective June 19, 2026) and its 2 other brand-application labels do not name vortioxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Linezolid), Hospira, Inc., effective June 19, 2026 (SPL set c401f1a8-cc37-461b-bfef-f2e156629bf8), via openFDA; the full label on DailyMed
What does the vortioxetine label say about linezolid?
Vortioxetine label, contraindicationsStarting TRINTELLIX in a patient who is being treated with MAOIs such as linezolid or intravenous methylene blue is also contraindicated because of an increased risk of serotonin syndrome [see Warnings and Precautions (5.2) ].
Vortioxetine label, drug interactionsIn a patient who is being treated with linezolid or intravenous methylene blue. [see Dosage and Administration (2.4), Contraindications (4), Warnings and Precautions (5.2) ] Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of TRINTELLIX with other serotonergic drugs increases the risk of serotonin syndrome. Intervention Monitor for symptoms of serotonin syndrome when TRINTELLIX is used concomitantly with other drugs that may affect the serotonergic neurotransmitter systems. …
Vortioxetine label, warnings and precautionsIf it is necessary to initiate treatment with an MAOI such as linezolid or intravenous methylene blue in a patient taking TRINTELLIX, discontinue TRINTELLIX before initiating treatment with the MAOI [see Contraindications (4), Drug Interactions (7.1) ].
Source: FDA drug label (Trintellix), Takeda Pharmaceuticals America, Inc., effective March 5, 2025 (SPL set 1a5b68e2-14d0-419d-9ec6-1ca97145e838), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Linezolid | Vortioxetine | |
|---|---|---|
| Labeled for | Bacterial infections | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.44 per tablet 600 mg tablet | $17.20 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once