Vortioxetine and Tranylcypromine Interaction
Drug interaction information between Vortioxetine and Tranylcypromine.
Vortioxetine and Tranylcypromine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vortioxetine and Tranylcypromine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications both raise serotonin levels in your body. Combining them can lead to a serious reaction known as serotonin syndrome.
FDA Label Information
[see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.2) ] Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of TRINTELLIX with other serotonergic drugs increases the risk of serotonin syndrome.
Vortioxetine Also Interacts With
- Carbamazepine moderate
- Linezolid moderate
- Rifampin moderate
- Phenelzine moderate
- Selegiline moderate
Tranylcypromine Also Interacts With
- Bupropion major
- Linezolid major
- Vilazodone major
- Epinephrine major
- Norepinephrine major
Frequently Asked Questions
What SPL severity band is on file for Vortioxetine + Tranylcypromine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Tranylcypromine has 42 labeled pairs on file vs Vortioxetine's 18. In the moderate band specifically: Vortioxetine has 7 (also Carbamazepine, Linezolid, Rifampin, Phenelzine); Tranylcypromine has 23 (also Buspirone, Cyclobenzaprine, Carbamazepine, Lithium).
What mechanism field is on file for Vortioxetine and Tranylcypromine?
These medications both raise serotonin levels in your body. Combining them can lead to a serious reaction known as serotonin syndrome.
Tranylcypromine carries more major-labeled pairs than Vortioxetine
SPL source-record counts only. This page's band is moderate · classes on file: Vortioxetine (Serotonin Modulator); Tranylcypromine (Monoamine Oxidase Inhibitor (MAOI)).
Tranylcypromine has 7 major-labeled pairs vs Vortioxetine's 0. This page itself is in the moderate band, not the major band.
0 major · 7 moderate · 11 minor · 18 total
- Other moderate peers for Vortioxetine
- Carbamazepine
- Linezolid
- Rifampin
- Phenelzine
7 major · 23 moderate · 12 minor · 42 total
- Other moderate peers for Tranylcypromine
- Buspirone
- Cyclobenzaprine
- Carbamazepine
- Lithium
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.