Vortioxetine and Selegiline Interaction
Drug interaction information between Vortioxetine and Selegiline.
Vortioxetine and Selegiline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vortioxetine and Selegiline. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these drugs work by increasing serotonin in your system. Using them at the same time can cause serotonin levels to become dangerously high.
What To Do
Avoid taking these two drugs together. Your healthcare provider will manage the timing of your doses to prevent a bad reaction.
FDA Label Information
[see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.2) ] Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of TRINTELLIX with other serotonergic drugs increases the risk of serotonin syndrome.
Vortioxetine Also Interacts With
- Carbamazepine moderate
- Linezolid moderate
- Rifampin moderate
- Phenelzine moderate
- Tranylcypromine moderate
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Trazodone moderate
Frequently Asked Questions
Can I take Vortioxetine and Selegiline together?
This is a moderate interaction. Avoid taking these two drugs together. Your healthcare provider will manage the timing of your doses to prevent a bad reaction.
How serious is the interaction between Vortioxetine and Selegiline?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Vortioxetine and Selegiline interact?
Both of these drugs work by increasing serotonin in your system. Using them at the same time can cause serotonin levels to become dangerously high.
Understanding the Vortioxetine and Selegiline Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Vortioxetine belongs to the Serotonin Modulator class and Selegiline belongs to the Selective MAO-B Inhibitor class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these drugs work by increasing serotonin in your system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Vortioxetine has 18 total documented interactions on file in this dataset, and Selegiline has 9. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid taking these two drugs together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Vortioxetine or Selegiline based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.