What the FDA labels say about taking them together
Selegiline and vortioxetine
Vortioxetine's FDA label of March 5, 2025 names selegiline in its drug interactions section; the selegiline labels PlainMeds reads (3) do not name vortioxetine. The vortioxetine label: “In a patient who is being treated with linezolid or intravenous methylene blue. Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact …”
Check it at the source: the selegiline FDA label on DailyMed (effective August 7, 2024, Rising Pharma Holdings, Inc.); the vortioxetine FDA label on DailyMed (effective March 5, 2025, Takeda Pharmaceuticals America, Inc.).
What does the selegiline label say about vortioxetine?
Selegiline's label (effective August 7, 2024) and its 2 other brand-application labels do not name vortioxetine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Selegiline Hydrochloride), Rising Pharma Holdings, Inc., effective August 7, 2024 (SPL set 23c4481f-d150-40c6-addb-b3e454ca914f), via openFDA; the full label on DailyMed
What does the vortioxetine label say about selegiline?
Vortioxetine label, drug interactionsIn a patient who is being treated with linezolid or intravenous methylene blue. [see Dosage and Administration (2.4), Contraindications (4), Warnings and Precautions (5.2) ] Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of TRINTELLIX with other serotonergic drugs increases the risk of serotonin syndrome. Intervention Monitor for symptoms of serotonin syndrome when TRINTELLIX is used concomitantly with other drugs that may affect the serotonergic neurotransmitter systems. …
Source: FDA drug label (Trintellix), Takeda Pharmaceuticals America, Inc., effective March 5, 2025 (SPL set 1a5b68e2-14d0-419d-9ec6-1ca97145e838), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Selegiline | Vortioxetine | |
|---|---|---|
| Labeled for | Parkinson's disease, Depression | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.756 per capsule 5 mg capsule | $17.20 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once