Vortioxetine and Selegiline Interaction
Drug interaction information between Vortioxetine and Selegiline.
Vortioxetine and Selegiline have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Vortioxetine and Selegiline. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs work by increasing serotonin in your system. Using them at the same time can cause serotonin levels to become dangerously high.
FDA Label Information
[see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.2) ] Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of TRINTELLIX with other serotonergic drugs increases the risk of serotonin syndrome.
Vortioxetine Also Interacts With
- Carbamazepine moderate
- Linezolid moderate
- Rifampin moderate
- Phenelzine moderate
- Tranylcypromine moderate
Selegiline Also Interacts With
- Desvenlafaxine moderate
- Levomilnacipran moderate
- Mirtazapine moderate
- Paroxetine moderate
- Trazodone moderate
Frequently Asked Questions
What SPL severity band is on file for Vortioxetine + Selegiline?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Vortioxetine has 18 labeled pairs on file vs Selegiline's 9. In the moderate band specifically: Vortioxetine has 7 (also Carbamazepine, Linezolid, Rifampin, Phenelzine); Selegiline has 6 (also Desvenlafaxine, Levomilnacipran, Mirtazapine, Paroxetine).
What mechanism field is on file for Vortioxetine and Selegiline?
Both of these drugs work by increasing serotonin in your system. Using them at the same time can cause serotonin levels to become dangerously high.
Vortioxetine's labeled portfolio outnumbers Selegiline
SPL source-record counts only. This page's band is moderate · classes on file: Vortioxetine (Serotonin Modulator); Selegiline (Selective MAO-B Inhibitor).
0 major · 7 moderate · 11 minor · 18 total
- Other moderate peers for Vortioxetine
- Carbamazepine
- Linezolid
- Rifampin
- Phenelzine
0 major · 6 moderate · 3 minor · 9 total
- Other moderate peers for Selegiline
- Desvenlafaxine
- Levomilnacipran
- Mirtazapine
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.