What the FDA labels say about taking them together
Nirmatrelvir/ritonavir and tamsulosin
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names tamsulosin in its drug interactions section; the tamsulosin label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Avoid concomitant use with PAXLOVID.”
Check it at the source: the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc); the tamsulosin FDA label on DailyMed (effective December 1, 2025, Synthon Pharmaceuticals, Inc.).
What does the nirmatrelvir/ritonavir label say about tamsulosin?
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Alpha 1- adrenoreceptor antagonist; Drugs within Class: tamsulosin; Effect on Concentration: ↑ tamsulosin; Clinical Comments: Avoid concomitant use with PAXLOVID.
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
What does the tamsulosin label say about nirmatrelvir/ritonavir?
Tamsulosin's label (effective December 1, 2025) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tamsulosin hydrochloride), Synthon Pharmaceuticals, Inc., effective December 1, 2025 (SPL set 13a5032d-0be1-4001-916e-459f0b1a051d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nirmatrelvir/ritonavir | Tamsulosin | |
|---|---|---|
| Labeled for | COVID-19 | Enlarged prostate (BPH) |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $49.24 per unit 300-100 mg dose pack | $0.05 per capsule 0.4 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once