Nirmatrelvir/Ritonavir and Fluticasone Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Fluticasone.
Nirmatrelvir/Ritonavir and Fluticasone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nirmatrelvir/Ritonavir and Fluticasone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication prevents your body from clearing the steroid fluticasone. This can lead to very high steroid levels, which may cause serious issues with your body's natural hormone production.
FDA Label Information
Corticosteroids primarily metabolized by CYP3A betamethasone, budesonide, ciclesonide, dexamethasone, fluticasone, methylprednisolone, mometasone, triamcinolone ↑ corticosteroid Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing’s syndrome and adrenal suppression.
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Fluticasone Also Interacts With
- Darunavir moderate
- Fluticasone/Salmeterol minor
- Fluticasone/Umeclidinium/Vilanterol minor
- Fluticasone/Vilanterol minor
- Itraconazole minor
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Fluticasone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Fluticasone's 7. In the moderate band specifically: Nirmatrelvir/Ritonavir has 30 (also Amlodipine, Tamsulosin, Apixaban, Clopidogrel); Fluticasone has 2 (also Darunavir).
What mechanism field is on file for Nirmatrelvir/Ritonavir and Fluticasone?
This medication prevents your body from clearing the steroid fluticasone. This can lead to very high steroid levels, which may cause serious issues with your body's natural hormone production.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Fluticasone
SPL source-record counts only. This page's band is moderate · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Fluticasone (Corticosteroid).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Fluticasone's 0. This page itself is in the moderate band, not the major band.
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Amlodipine
- Tamsulosin
- Apixaban
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.