Nirmatrelvir/Ritonavir and Amlodipine Interaction
Drug interaction information between Nirmatrelvir/Ritonavir and Amlodipine.
Nirmatrelvir/Ritonavir and Amlodipine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Nirmatrelvir/Ritonavir and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication slows down how fast your body processes amlodipine. This can cause the blood pressure medicine to build up to high levels in your blood.
FDA Label Information
Calcium channel blockers amlodipine, diltiazem, felodipine, nicardipine, nifedipine, verapamil ↑ calcium channel blocker Caution is warranted and clinical monitoring of patients is recommended.
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Sildenafil minor
Frequently Asked Questions
What SPL severity band is on file for Nirmatrelvir/Ritonavir + Amlodipine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Amlodipine's 15. In the moderate band specifically: Nirmatrelvir/Ritonavir has 30 (also Tamsulosin, Fluticasone, Apixaban, Clopidogrel); Amlodipine has 1.
What mechanism field is on file for Nirmatrelvir/Ritonavir and Amlodipine?
This medication slows down how fast your body processes amlodipine. This can cause the blood pressure medicine to build up to high levels in your blood.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is moderate · classes on file: Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)); Amlodipine (Calcium Channel Blocker).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Amlodipine's 4. This page itself is in the moderate band, not the major band.
23 major · 30 moderate · 33 minor · 86 total
- Other moderate peers for Nirmatrelvir/Ritonavir
- Tamsulosin
- Fluticasone
- Apixaban
- Clopidogrel
4 major · 1 moderate · 10 minor · 15 total
Amlodipine has no other moderate-band peer in this dataset besides Nirmatrelvir/Ritonavir.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.