What the FDA labels say about taking them together
Gabapentin and norethindrone
Gabapentin's FDA label of May 12, 2026 names norethindrone in its drug interactions section; the norethindrone labels PlainMeds reads (2) do not name gabapentin. The gabapentin label: “Gabapentin immediate release (400 mg three times daily) had no effect on the pharmacokinetics of norethindrone (2.5 mg) or ethinyl estradiol (50 mcg) administered as a single tablet, except that the C max of …”
Check it at the source: the gabapentin FDA label on DailyMed (effective May 12, 2026, Viatris Specialty LLC); the norethindrone FDA label on DailyMed (effective January 31, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the gabapentin label say about norethindrone?
Gabapentin label, drug interactionsOral Contraceptive Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of gabapentin (400 mg three times a day;
Gralise label (Almatica Pharma LLC, June 30, 2026), drug interactionsGabapentin immediate release (400 mg three times daily) had no effect on the pharmacokinetics of norethindrone (2.5 mg) or ethinyl estradiol (50 mcg) administered as a single tablet, except that the C max of norethindrone was increased by 13%.
Source: FDA drug label (Gralise, NDA022544), Almatica Pharma LLC, effective June 30, 2026 (SPL set 466273b1-c9fc-3930-c94b-aa11394d5140), via openFDA
Source: FDA drug label (Neurontin), Viatris Specialty LLC, effective May 12, 2026 (SPL set 97935fd9-1d4a-43b6-a5d9-de994591187b), via openFDA; the full label on DailyMed
What does the norethindrone label say about gabapentin?
Norethindrone's label (effective January 31, 2026) and its 1 other brand-application label do not name gabapentin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Norethindrone), Glenmark Pharmaceuticals Inc., USA, effective January 31, 2026 (SPL set 0d2f8fea-3675-40d2-afd9-9fcb148dbd4b), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gabapentin | Norethindrone | |
|---|---|---|
| Labeled for | Nerve pain and fibromyalgia, Seizures and epilepsy | Birth control |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0218 per capsule 100 mg capsule | $0.290 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once