Gabapentin and Norethindrone Interaction
Drug interaction information between Gabapentin and Norethindrone.
Gabapentin and Norethindrone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gabapentin and Norethindrone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Gabapentin slightly raises the peak level of the birth control hormone in your blood, but the change is very small.
What To Do
No changes are needed because this small increase is not expected to cause any problems.
FDA Label Information
Oral Contraceptive Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of gabapentin (400 mg three times a day; N=13). The C max of norethindrone was 13% higher when it was coadministered with gabapentin; this interaction is not expected to be of clinical importance.
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Morphine minor
Norethindrone Also Interacts With
- Voriconazole major
- Atorvastatin minor
- Colchicine minor
- Colesevelam minor
- Darunavir minor
Frequently Asked Questions
Can I take Gabapentin and Norethindrone together?
This is a minor interaction. No changes are needed because this small increase is not expected to cause any problems.
How serious is the interaction between Gabapentin and Norethindrone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Gabapentin and Norethindrone interact?
Gabapentin slightly raises the peak level of the birth control hormone in your blood, but the change is very small.
Understanding the Gabapentin and Norethindrone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Gabapentin belongs to the Anticonvulsant / Nerve Pain Agent class and Norethindrone belongs to the Progestin-Only Oral Contraceptive class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Gabapentin slightly raises the peak level of the birth control hormone in your blood, but the change is very small. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Gabapentin has 19 total documented interactions on file in this dataset, and Norethindrone has 10. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No changes are needed because this small increase is not expected to cause any problems. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Gabapentin or Norethindrone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.