Gabapentin and Norethindrone Interaction
Drug interaction information between Gabapentin and Norethindrone.
Gabapentin and Norethindrone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gabapentin and Norethindrone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Gabapentin slightly raises the peak level of the birth control hormone in your blood, but the change is very small.
FDA Label Information
Oral Contraceptive Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of gabapentin (400 mg three times a day; N=13). The C max of norethindrone was 13% higher when it was coadministered with gabapentin; this interaction is not expected to be of clinical importance.
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Morphine minor
Norethindrone Also Interacts With
- Voriconazole major
- Atorvastatin minor
- Colchicine minor
- Colesevelam minor
- Darunavir minor
Frequently Asked Questions
What SPL severity band is on file for Gabapentin + Norethindrone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Gabapentin has 19 labeled pairs on file vs Norethindrone's 10. In the minor band specifically: Gabapentin has 18 (also Oxycodone, Estradiol, Naproxen, Morphine); Norethindrone has 9 (also Atorvastatin, Colchicine, Colesevelam, Darunavir).
What mechanism field is on file for Gabapentin and Norethindrone?
Gabapentin slightly raises the peak level of the birth control hormone in your blood, but the change is very small.
Norethindrone carries more major-labeled pairs than Gabapentin
SPL source-record counts only. This page's band is minor · classes on file: Gabapentin (Anticonvulsant / Nerve Pain Agent); Norethindrone (Progestin-Only Oral Contraceptive).
Norethindrone has 1 major-labeled pair vs Gabapentin's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 18 minor · 19 total
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Norethindrone
- Atorvastatin
- Colchicine
- Colesevelam
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.