Gabapentin and Naproxen Interaction
Drug interaction information between Gabapentin and Naproxen.
Gabapentin and Naproxen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gabapentin and Naproxen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking naproxen can cause the body to absorb a slightly higher amount of gabapentin than it normally would. This could potentially increase the effects or side effects of the gabapentin.
FDA Label Information
Naproxen Coadministration (N=18) of naproxen sodium capsules (250 mg) with Gabapentin (125 mg) appears to increase the amount of gabapentin absorbed by 12% to 15%. Gabapentin had no effect on naproxen pharmacokinetic parameters.
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Estradiol minor
- Norethindrone minor
- Morphine minor
Naproxen Also Interacts With
- Methotrexate moderate
- Magnesium Oxide moderate
- Diflunisal moderate
- Sucralfate moderate
- Cholestyramine moderate
Frequently Asked Questions
What SPL severity band is on file for Gabapentin + Naproxen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Naproxen has 23 labeled pairs on file vs Gabapentin's 19. In the minor band specifically: Gabapentin has 18 (also Oxycodone, Estradiol, Norethindrone, Morphine); Naproxen has 18 (also Meloxicam, Furosemide, Aspirin, Propranolol).
What mechanism field is on file for Gabapentin and Naproxen?
Taking naproxen can cause the body to absorb a slightly higher amount of gabapentin than it normally would. This could potentially increase the effects or side effects of the gabapentin.
Naproxen's labeled portfolio outnumbers Gabapentin
SPL source-record counts only. This page's band is minor · classes on file: Gabapentin (Anticonvulsant / Nerve Pain Agent); Naproxen (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Oxycodone
- Estradiol
- Norethindrone
- Morphine
0 major · 5 moderate · 18 minor · 23 total
- Other minor peers for Naproxen
- Meloxicam
- Furosemide
- Aspirin
- Propranolol
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.