What the FDA labels say about taking them together
Gabapentin and naproxen
Gabapentin's FDA label of May 12, 2026 names naproxen in its drug interactions section; the naproxen labels PlainMeds reads (4) do not name gabapentin. The gabapentin label: “Coadministration of single doses of naproxen (250 mg) and gabapentin immediate release (125 mg) to 18 volunteers increased gabapentin absorption by 12% to 15%.”
Check it at the source: the gabapentin FDA label on DailyMed (effective May 12, 2026, Viatris Specialty LLC); the naproxen FDA label on DailyMed (effective March 12, 2026, Bayer HealthCare LLC.).
What does the gabapentin label say about naproxen?
Gabapentin label, drug interactionsNaproxen Coadministration (N=18) of naproxen sodium capsules (250 mg) with NEURONTIN (125 mg) appears to increase the amount of gabapentin absorbed by 12% to 15%.
Gralise label (Almatica Pharma LLC, June 30, 2026), drug interactionsCoadministration of single doses of naproxen (250 mg) and gabapentin immediate release (125 mg) to 18 volunteers increased gabapentin absorption by 12% to 15%.
Source: FDA drug label (Gralise, NDA022544), Almatica Pharma LLC, effective June 30, 2026 (SPL set 466273b1-c9fc-3930-c94b-aa11394d5140), via openFDA
Source: FDA drug label (Gabapentin, NDA021129), Mylan Pharmaceuticals Inc., effective April 12, 2025 (SPL set cff7de45-148b-4e96-88fd-6052bf75b5f7), via openFDA
Source: FDA drug label (Neurontin), Viatris Specialty LLC, effective May 12, 2026 (SPL set 97935fd9-1d4a-43b6-a5d9-de994591187b), via openFDA; the full label on DailyMed
What does the naproxen label say about gabapentin?
Naproxen's label (effective March 12, 2026) and its 3 other brand-application labels do not name gabapentin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Aleve Caplets), Bayer HealthCare LLC., effective March 12, 2026 (SPL set 02941928-128a-2c88-e063-6294a90ac6ba), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Gabapentin | Naproxen | |
|---|---|---|
| Labeled for | Nerve pain and fibromyalgia, Seizures and epilepsy | Fever, Rheumatoid arthritis, Osteoarthritis, Gout, Pain, Cough and cold |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0218 per capsule 100 mg capsule | $0.0565 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once