Gabapentin and Oxycodone Interaction
Drug interaction information between Gabapentin and Oxycodone.
Gabapentin and Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gabapentin and Oxycodone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medications slow down the central nervous system, which can lead to dangerous breathing problems and extreme sleepiness. Taking them together increases the risk of these life-threatening side effects.
What To Do
Your doctor should monitor you closely for signs of breathing trouble and may need to adjust your dosages.
FDA Label Information
7 DRUG INTERACTIONS Concentrations increased by morphine; may need dose adjustment (5.4, 7.1 ) 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ]. 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ].
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Estradiol minor
- Naproxen minor
- Norethindrone minor
- Morphine minor
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Frequently Asked Questions
Can I take Gabapentin and Oxycodone together?
This is a minor interaction. Your doctor should monitor you closely for signs of breathing trouble and may need to adjust your dosages.
How serious is the interaction between Gabapentin and Oxycodone?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Gabapentin and Oxycodone interact?
Both of these medications slow down the central nervous system, which can lead to dangerous breathing problems and extreme sleepiness. Taking them together increases the risk of these life-threatening side effects.
Understanding the Gabapentin and Oxycodone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Gabapentin belongs to the Anticonvulsant / Nerve Pain Agent class and Oxycodone belongs to the Opioid Analgesic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medications slow down the central nervous system, which can lead to dangerous breathing problems and extreme sleepiness. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Gabapentin has 19 total documented interactions on file in this dataset, and Oxycodone has 28. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you closely for signs of breathing trouble and may need to adjust your dosages. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Gabapentin or Oxycodone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.