Gabapentin and Oxycodone Interaction
Drug interaction information between Gabapentin and Oxycodone.
Gabapentin and Oxycodone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gabapentin and Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medications slow down the central nervous system, which can lead to dangerous breathing problems and extreme sleepiness. Taking them together increases the risk of these life-threatening side effects.
FDA Label Information
7 DRUG INTERACTIONS Concentrations increased by morphine; may need dose adjustment (5.4, 7.1 ) 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ]. 7.1 Opioids Respiratory depression and sedation, sometimes resulting in death, have been reported following coadministration of gabapentin with opioids (e.g., morphine, hydrocodone, oxycodone, buprenorphine) [ see Warnings and Precautions (5.7) ].
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Estradiol minor
- Naproxen minor
- Norethindrone minor
- Morphine minor
Oxycodone Also Interacts With
- Carbamazepine moderate
- Rifampin moderate
- Buprenorphine moderate
- Butorphanol moderate
- Nalbuphine moderate
Frequently Asked Questions
What SPL severity band is on file for Gabapentin + Oxycodone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Oxycodone has 28 labeled pairs on file vs Gabapentin's 19. In the minor band specifically: Gabapentin has 18 (also Estradiol, Naproxen, Norethindrone, Morphine); Oxycodone has 22 (also Trazodone, Tramadol, Cyclobenzaprine, Pregabalin).
What mechanism field is on file for Gabapentin and Oxycodone?
Both of these medications slow down the central nervous system, which can lead to dangerous breathing problems and extreme sleepiness. Taking them together increases the risk of these life-threatening side effects.
Oxycodone's labeled portfolio outnumbers Gabapentin
SPL source-record counts only. This page's band is minor · classes on file: Gabapentin (Anticonvulsant / Nerve Pain Agent); Oxycodone (Opioid Analgesic).
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Estradiol
- Naproxen
- Norethindrone
- Morphine
0 major · 6 moderate · 22 minor · 28 total
- Other minor peers for Oxycodone
- Trazodone
- Tramadol
- Cyclobenzaprine
- Pregabalin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.