Gabapentin and Estradiol Interaction
Drug interaction information between Gabapentin and Estradiol.
Gabapentin and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gabapentin and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Based on clinical studies, gabapentin does not change how the body processes or reacts to birth control hormones like estradiol. There is no significant interaction between these two drugs.
FDA Label Information
Oral Contraceptive Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of gabapentin (400 mg three times a day; N=13).
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Naproxen minor
- Norethindrone minor
- Morphine minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Gabapentin + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Gabapentin's 19. In the minor band specifically: Gabapentin has 18 (also Oxycodone, Naproxen, Norethindrone, Morphine); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Gabapentin and Estradiol?
Based on clinical studies, gabapentin does not change how the body processes or reacts to birth control hormones like estradiol. There is no significant interaction between these two drugs.
Estradiol carries more major-labeled pairs than Gabapentin
SPL source-record counts only. This page's band is minor · classes on file: Gabapentin (Anticonvulsant / Nerve Pain Agent); Estradiol (Estrogen Hormone).
Estradiol has 1 major-labeled pair vs Gabapentin's 0. This page itself is in the minor band, not the major band.
0 major · 1 moderate · 18 minor · 19 total
- Other minor peers for Gabapentin
- Oxycodone
- Naproxen
- Norethindrone
- Morphine
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.