Gabapentin and Estradiol Interaction
Drug interaction information between Gabapentin and Estradiol.
Gabapentin and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Gabapentin and Estradiol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Based on clinical studies, gabapentin does not change how the body processes or reacts to birth control hormones like estradiol. There is no significant interaction between these two drugs.
What To Do
No special dose changes are usually needed when taking these two medications together.
FDA Label Information
Oral Contraceptive Based on AUC and half-life, multiple-dose pharmacokinetic profiles of norethindrone and ethinyl estradiol following administration of tablets containing 2.5 mg of norethindrone acetate and 50 mcg of ethinyl estradiol were similar with and without coadministration of gabapentin (400 mg three times a day; N=13).
Gabapentin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Oxycodone minor
- Naproxen minor
- Norethindrone minor
- Morphine minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
Can I take Gabapentin and Estradiol together?
This is a minor interaction. No special dose changes are usually needed when taking these two medications together.
How serious is the interaction between Gabapentin and Estradiol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Gabapentin and Estradiol interact?
Based on clinical studies, gabapentin does not change how the body processes or reacts to birth control hormones like estradiol. There is no significant interaction between these two drugs.
Understanding the Gabapentin and Estradiol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Gabapentin belongs to the Anticonvulsant / Nerve Pain Agent class and Estradiol belongs to the Estrogen Hormone class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Based on clinical studies, gabapentin does not change how the body processes or reacts to birth control hormones like estradiol. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Gabapentin has 19 total documented interactions on file in this dataset, and Estradiol has 54. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: No special dose changes are usually needed when taking these two medications together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Gabapentin or Estradiol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.