Gabapentin and Acetaminophen/Oxycodone Interaction
Drug interaction information between Gabapentin and Acetaminophen/Oxycodone.
Gabapentin and Acetaminophen/Oxycodone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Gabapentin and Acetaminophen/Oxycodone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs slow down the central nervous system. Taking them together can cause extreme sleepiness, dangerously slow breathing, coma, or even death.
FDA Label Information
Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants such as benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.
Gabapentin Also Interacts With
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
- Morphine minor
Acetaminophen/Oxycodone Also Interacts With
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Oxycodone minor
Frequently Asked Questions
What SPL severity band is on file for Gabapentin + Acetaminophen/Oxycodone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen/Oxycodone has 23 labeled pairs on file vs Gabapentin's 19. In the moderate band specifically: Gabapentin has 1; Acetaminophen/Oxycodone has 2 (also Pregabalin).
What mechanism field is on file for Gabapentin and Acetaminophen/Oxycodone?
Both of these drugs slow down the central nervous system. Taking them together can cause extreme sleepiness, dangerously slow breathing, coma, or even death.
Acetaminophen/Oxycodone's labeled portfolio outnumbers Gabapentin
SPL source-record counts only. This page's band is moderate · classes on file: Gabapentin (Anticonvulsant / Nerve Pain Agent); Acetaminophen/Oxycodone (Opioid Analgesic Combination).
0 major · 1 moderate · 18 minor · 19 total
Gabapentin has no other moderate-band peer in this dataset besides Acetaminophen/Oxycodone.
0 major · 2 moderate · 21 minor · 23 total
- Other moderate peers for Acetaminophen/Oxycodone
- Pregabalin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.