Gabapentin and Acetaminophen/Oxycodone Interaction
Drug interaction information between Gabapentin and Acetaminophen/Oxycodone.
Gabapentin and Acetaminophen/Oxycodone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Gabapentin and Acetaminophen/Oxycodone. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these drugs slow down the central nervous system. Taking them together can cause extreme sleepiness, dangerously slow breathing, coma, or even death.
What To Do
Use these drugs together only if your doctor says it is absolutely necessary. Monitor closely for signs of extreme drowsiness or trouble breathing.
FDA Label Information
Benzodiazepines and Other Central Nervous System (CNS) Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants such as benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death.
Gabapentin Also Interacts With
- Oxycodone minor
- Estradiol minor
- Naproxen minor
- Norethindrone minor
- Morphine minor
Acetaminophen/Oxycodone Also Interacts With
- Pregabalin moderate
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Oxycodone minor
Frequently Asked Questions
Can I take Gabapentin and Acetaminophen/Oxycodone together?
This is a moderate interaction. Use these drugs together only if your doctor says it is absolutely necessary. Monitor closely for signs of extreme drowsiness or trouble breathing.
How serious is the interaction between Gabapentin and Acetaminophen/Oxycodone?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Gabapentin and Acetaminophen/Oxycodone interact?
Both of these drugs slow down the central nervous system. Taking them together can cause extreme sleepiness, dangerously slow breathing, coma, or even death.
Understanding the Gabapentin and Acetaminophen/Oxycodone Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Gabapentin belongs to the Anticonvulsant / Nerve Pain Agent class and Acetaminophen/Oxycodone belongs to the Opioid Analgesic Combination class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these drugs slow down the central nervous system. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Gabapentin has 19 total documented interactions on file in this dataset, and Acetaminophen/Oxycodone has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Use these drugs together only if your doctor says it is absolutely necessary. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Gabapentin or Acetaminophen/Oxycodone based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.