Thioridazine and Bupropion Interaction
Drug interaction information between Thioridazine and Bupropion.
Thioridazine and Bupropion have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Thioridazine and Bupropion. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Bupropion blocks the body's way of getting rid of thioridazine, which can lead to higher and potentially unsafe levels of the drug.
FDA Label Information
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Thioridazine Also Interacts With
- Fluoxetine major
- Paroxetine major
- Rolapitant major
- Abiraterone moderate
- Darifenacin moderate
Bupropion Also Interacts With
- Tranylcypromine major
- Theophylline moderate
- Isavuconazonium moderate
- Metoprolol minor
- Sertraline minor
Frequently Asked Questions
What SPL severity band is on file for Thioridazine + Bupropion?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Bupropion has 35 labeled pairs on file vs Thioridazine's 17. In the minor band specifically: Thioridazine has 11 (also Propranolol, Pindolol, Carbamazepine, Clozapine); Bupropion has 32 (also Metoprolol, Sertraline, Fluoxetine, Clopidogrel).
What mechanism field is on file for Thioridazine and Bupropion?
Bupropion blocks the body's way of getting rid of thioridazine, which can lead to higher and potentially unsafe levels of the drug.
Thioridazine carries more major-labeled pairs than Bupropion
SPL source-record counts only. This page's band is minor · classes on file: Thioridazine (Typical Antipsychotic (Phenothiazine)); Bupropion (Norepinephrine-Dopamine Reuptake Inhibitor (NDRI)).
Thioridazine has 3 major-labeled pairs vs Bupropion's 1. This page itself is in the minor band, not the major band.
3 major · 3 moderate · 11 minor · 17 total
- Other minor peers for Thioridazine
- Propranolol
- Pindolol
- Carbamazepine
- Clozapine
1 major · 2 moderate · 32 minor · 35 total
- Other minor peers for Bupropion
- Metoprolol
- Sertraline
- Fluoxetine
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.