Thioridazine and Rolapitant Interaction
Drug interaction information between Thioridazine and Rolapitant.
Thioridazine and Rolapitant have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Thioridazine and Rolapitant. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rolapitant prevents the body from processing thioridazine, causing it to build up to unsafe levels. High levels of this drug can cause life-threatening heart rhythm issues.
Thioridazine Also Interacts With
- Fluoxetine major
- Paroxetine major
- Abiraterone moderate
- Darifenacin moderate
- Tetrabenazine moderate
Rolapitant Also Interacts With
- Pimozide major
- Rifampin moderate
- Rosuvastatin minor
- Warfarin minor
- Methotrexate minor
Frequently Asked Questions
What SPL severity band is on file for Thioridazine + Rolapitant?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Thioridazine has 17 labeled pairs on file vs Rolapitant's 9. In the major band specifically: Thioridazine has 3 (also Fluoxetine, Paroxetine); Rolapitant has 2 (also Pimozide).
What mechanism field is on file for Thioridazine and Rolapitant?
Rolapitant prevents the body from processing thioridazine, causing it to build up to unsafe levels. High levels of this drug can cause life-threatening heart rhythm issues.
Thioridazine carries more major-labeled pairs than Rolapitant
SPL source-record counts only. This page's band is major · classes on file: Thioridazine (Typical Antipsychotic (Phenothiazine)); Rolapitant (NK1 Receptor Antagonist (Antiemetic)).
Thioridazine has 3 major-labeled pairs vs Rolapitant's 2.
3 major · 3 moderate · 11 minor · 17 total
- Other major peers for Thioridazine
- Fluoxetine
- Paroxetine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.