Lidocaine Topical and Valproate Interaction
Drug interaction information between Lidocaine Topical and Valproate.
Lidocaine Topical and Valproate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lidocaine Topical and Valproate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These medications can both lead to a rare blood disorder that prevents oxygen from moving through your body. Taking them at the same time makes this side effect more likely.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Chloroquine moderate
- Mexiletine moderate
- Nitroglycerin moderate
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Risperidone moderate
- Aspirin minor
Frequently Asked Questions
What SPL severity band is on file for Lidocaine Topical + Valproate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Valproate has 41 labeled pairs on file vs Lidocaine Topical's 10. In the moderate band specifically: Lidocaine Topical has 10 (also Acetaminophen, Nitrofurantoin, Chloroquine, Mexiletine); Valproate has 3 (also Clarithromycin, Risperidone).
What mechanism field is on file for Lidocaine Topical and Valproate?
These medications can both lead to a rare blood disorder that prevents oxygen from moving through your body. Taking them at the same time makes this side effect more likely.
Valproate carries more major-labeled pairs than Lidocaine Topical
SPL source-record counts only. This page's band is moderate · classes on file: Lidocaine Topical (Topical Anesthetic); Valproate (Anticonvulsant / Mood Stabilizer).
Valproate has 2 major-labeled pairs vs Lidocaine Topical's 0. This page itself is in the moderate band, not the major band.
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Acetaminophen
- Nitrofurantoin
- Chloroquine
- Mexiletine
2 major · 3 moderate · 36 minor · 41 total
- Other moderate peers for Valproate
- Clarithromycin
- Risperidone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.