Lidocaine Topical and Mexiletine Interaction
Drug interaction information between Lidocaine Topical and Mexiletine.
Lidocaine Topical and Mexiletine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lidocaine Topical and Mexiletine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs have similar effects on the body, so taking them together can cause their toxic side effects to build up. This makes the risk of a bad reaction much higher than taking just one.
FDA Label Information
Drug Interactions Antiarrhythmic Drugs LIDODERM should be used with caution in patients receiving Class I antiarrhythmic drugs (such as tocainide and mexiletine) since the toxic effects are additive and potentially synergistic.
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Nitrofurantoin moderate
- Valproate moderate
- Chloroquine moderate
- Nitroglycerin moderate
Mexiletine Also Interacts With
- Propranolol minor
- Digoxin minor
- Propafenone minor
- Theophylline minor
- Cimetidine minor
Frequently Asked Questions
What SPL severity band is on file for Lidocaine Topical + Mexiletine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Mexiletine has 14 labeled pairs on file vs Lidocaine Topical's 10. In the moderate band specifically: Lidocaine Topical has 10 (also Acetaminophen, Nitrofurantoin, Valproate, Chloroquine); Mexiletine has 1.
What mechanism field is on file for Lidocaine Topical and Mexiletine?
These drugs have similar effects on the body, so taking them together can cause their toxic side effects to build up. This makes the risk of a bad reaction much higher than taking just one.
Mexiletine's labeled portfolio outnumbers Lidocaine Topical
SPL source-record counts only. This page's band is moderate · classes on file: Lidocaine Topical (Topical Anesthetic); Mexiletine (Class IB Antiarrhythmic).
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Acetaminophen
- Nitrofurantoin
- Valproate
- Chloroquine
0 major · 1 moderate · 13 minor · 14 total
Mexiletine has no other moderate-band peer in this dataset besides Lidocaine Topical.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.