Lidocaine Topical and Nitrofurantoin Interaction
Drug interaction information between Lidocaine Topical and Nitrofurantoin.
Lidocaine Topical and Nitrofurantoin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lidocaine Topical and Nitrofurantoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can cause a blood problem that makes it hard for your body to get enough oxygen. Using them together increases the risk of this serious condition.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Lidocaine Topical Also Interacts With
- Acetaminophen moderate
- Valproate moderate
- Chloroquine moderate
- Mexiletine moderate
- Nitroglycerin moderate
Nitrofurantoin Also Interacts With
- Dapsone Topical moderate
- Probenecid minor
- Methylprednisolone minor
Frequently Asked Questions
What SPL severity band is on file for Lidocaine Topical + Nitrofurantoin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lidocaine Topical has 10 labeled pairs on file vs Nitrofurantoin's 4. In the moderate band specifically: Lidocaine Topical has 10 (also Acetaminophen, Valproate, Chloroquine, Mexiletine); Nitrofurantoin has 2 (also Dapsone Topical).
What mechanism field is on file for Lidocaine Topical and Nitrofurantoin?
Both drugs can cause a blood problem that makes it hard for your body to get enough oxygen. Using them together increases the risk of this serious condition.
Lidocaine Topical's labeled portfolio outnumbers Nitrofurantoin
SPL source-record counts only. This page's band is moderate · classes on file: Lidocaine Topical (Topical Anesthetic); Nitrofurantoin (Nitrofuran Antibiotic).
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Acetaminophen
- Valproate
- Chloroquine
- Mexiletine
0 major · 2 moderate · 2 minor · 4 total
- Other moderate peers for Nitrofurantoin
- Dapsone Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.