Lidocaine Topical and Acetaminophen Interaction
Drug interaction information between Lidocaine Topical and Acetaminophen.
Lidocaine Topical and Acetaminophen have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Lidocaine Topical and Acetaminophen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs can change how your red blood cells carry oxygen, which might lead to a rare but serious blood condition.
FDA Label Information
Drugs That May Cause Methemoglobinemia When Used with LIDODERM Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics: Examples of Drugs Associated with Methemoglobinemia : Class Examples Nitrates/Nitrites nitric oxide, nitroglycerin, nitroprusside, nitrous oxide Local anesthetics articaine, benzocaine, bupivacaine, lidocaine, mepivacaine, prilocaine, procaine, ropivacaine, tetracaine Antineoplastic agents cyclophosphamide, flutamide, hydroxyurea,...
Lidocaine Topical Also Interacts With
- Nitrofurantoin moderate
- Valproate moderate
- Chloroquine moderate
- Mexiletine moderate
- Nitroglycerin moderate
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
- Codeine minor
Frequently Asked Questions
What SPL severity band is on file for Lidocaine Topical + Acetaminophen?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Acetaminophen has 23 labeled pairs on file vs Lidocaine Topical's 10. In the moderate band specifically: Lidocaine Topical has 10 (also Nitrofurantoin, Valproate, Chloroquine, Mexiletine); Acetaminophen has 2 (also Dapsone Topical).
What mechanism field is on file for Lidocaine Topical and Acetaminophen?
Both of these drugs can change how your red blood cells carry oxygen, which might lead to a rare but serious blood condition.
Acetaminophen's labeled portfolio outnumbers Lidocaine Topical
SPL source-record counts only. This page's band is moderate · classes on file: Lidocaine Topical (Topical Anesthetic); Acetaminophen (Analgesic / Antipyretic).
0 major · 10 moderate · 0 minor · 10 total
- Other moderate peers for Lidocaine Topical
- Nitrofurantoin
- Valproate
- Chloroquine
- Mexiletine
0 major · 2 moderate · 21 minor · 23 total
- Other moderate peers for Acetaminophen
- Dapsone Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.