Spironolactone and Spironolactone Interaction
Drug interaction information between Spironolactone and Spironolactone.
Spironolactone and Spironolactone have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Spironolactone and Spironolactone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Pain relievers like aspirin or ibuprofen can stop this medicine from working well to lower blood pressure or remove extra fluid.
FDA Label Information
• NSAIDs: May reduce the diuretic, natriuretic and antihypertensive effect of ALDACTONE ( 7.3 ). • Digoxin: ALDACTONE can interfere with radioimmunologic assays of digoxin exposure ( 7.4 ). • Acetylsalicylic Acid (ASA): ASA may reduce the efficacy of ALDACTONE ( 7.6 ).
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Abiraterone moderate
- Digoxin minor
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Spironolactone (Acne) + Spironolactone?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Spironolactone's 7. In the minor band specifically: Spironolactone has 3 (also Digoxin, Cholestyramine); Spironolactone has 14 (also Digoxin, Cholestyramine, Amlodipine/Valsartan, Enalapril).
What mechanism field is on file for Spironolactone (Acne) and Spironolactone?
Pain relievers like aspirin or ibuprofen can stop this medicine from working well to lower blood pressure or remove extra fluid.
Spironolactone's labeled portfolio outnumbers Spironolactone
SPL source-record counts only. This page's band is minor · classes on file: Spironolactone (Anti-Androgen); Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist).
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Spironolactone
- Digoxin
- Cholestyramine
0 major · 9 moderate · 14 minor · 23 total
- Other minor peers for Spironolactone
- Digoxin
- Cholestyramine
- Amlodipine/Valsartan
- Enalapril
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.