Spironolactone and Lithium Interaction
Drug interaction information between Spironolactone and Lithium.
Spironolactone and Lithium have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Spironolactone and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication slows down how fast your kidneys get rid of lithium. This can lead to toxic levels of lithium in your system.
FDA Label Information
• Lithium: Increased risk of lithium toxicity ( 7.2 ). Examples of drugs that can increase potassium include: • ACE inhibitors • angiotensin receptor blockers • non-steroidal anti-inflammatory drugs (NSAIDs) • heparin and low molecular weight heparin • trimethoprim 7.2 Lithium Like other diuretics, ALDACTONE reduces the renal clearance of lithium, thus increasing the risk of lithium toxicity. Monitor lithium levels periodically when ALDACTONE is coadministered [see Clinical Pharmacology (12.3) ] .
Spironolactone Also Interacts With
- Trimethoprim moderate
- Heparin moderate
- Abiraterone moderate
- Spironolactone minor
- Digoxin minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Spironolactone (Acne) + Lithium?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Spironolactone's 7. In the moderate band specifically: Spironolactone has 4 (also Trimethoprim, Heparin, Abiraterone); Lithium has 23 (also Amiloride, Amiodarone, Amlodipine/Valsartan, Azilsartan).
What mechanism field is on file for Spironolactone (Acne) and Lithium?
This medication slows down how fast your kidneys get rid of lithium. This can lead to toxic levels of lithium in your system.
Lithium carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is moderate · classes on file: Spironolactone (Anti-Androgen); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Spironolactone's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Spironolactone
- Trimethoprim
- Heparin
- Abiraterone
2 major · 23 moderate · 65 minor · 90 total
- Other moderate peers for Lithium
- Amiloride
- Amiodarone
- Amlodipine/Valsartan
- Azilsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.