Spironolactone and Cholestyramine Interaction
Drug interaction information between Spironolactone and Cholestyramine.
Spironolactone and Cholestyramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Spironolactone and Cholestyramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using these medicines at the same time can cause your blood to become too acidic and hold onto too much potassium.
FDA Label Information
• Cholestyramine: Hyperkalemic metabolic acidosis has been reported with concomitant use ( 7.5 ). 7.5 Cholestyramine Hyperkalemic metabolic acidosis has been reported in patients given ALDACTONE concurrently with cholestyramine.
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Abiraterone moderate
- Spironolactone minor
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Raloxifene moderate
- Propranolol minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Spironolactone (Acne) + Cholestyramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Spironolactone's 7. In the minor band specifically: Spironolactone has 3 (also Spironolactone, Digoxin); Cholestyramine has 31 (also Propranolol, Warfarin, Tetracycline, Phenobarbital).
What mechanism field is on file for Spironolactone (Acne) and Cholestyramine?
Using these medicines at the same time can cause your blood to become too acidic and hold onto too much potassium.
Cholestyramine's labeled portfolio outnumbers Spironolactone
SPL source-record counts only. This page's band is minor · classes on file: Spironolactone (Anti-Androgen); Cholestyramine (Bile Acid Sequestrant).
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Spironolactone
- Spironolactone
- Digoxin
0 major · 3 moderate · 31 minor · 34 total
- Other minor peers for Cholestyramine
- Propranolol
- Warfarin
- Tetracycline
- Phenobarbital
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.