Spironolactone and Digoxin Interaction
Drug interaction information between Spironolactone and Digoxin.
Spironolactone and Digoxin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Spironolactone and Digoxin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Spironolactone can mess with the lab tests used to measure digoxin, making it look like there is more medicine in your blood than there actually is.
FDA Label Information
Digoxin: Spironolactone can interfere with radioimmunologic assays of digoxin exposure ( 7.4 ). 7.4 Digoxin Spironolactone and its metabolites interfere with radioimmunoassays for digoxin and increase the apparent exposure to digoxin. It is unknown to what extent, if any, spironolactone may increase actual digoxin exposure.
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Frequently Asked Questions
What SPL severity band is on file for Spironolactone + Digoxin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Spironolactone's 23. In the minor band specifically: Spironolactone has 14 (also Cholestyramine, Amlodipine/Valsartan, Enalapril, Felodipine); Digoxin has 105 (also Metformin, Omeprazole, Ibuprofen, Diclofenac).
What mechanism field is on file for Spironolactone and Digoxin?
Spironolactone can mess with the lab tests used to measure digoxin, making it look like there is more medicine in your blood than there actually is.
Digoxin carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is minor · classes on file: Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist); Digoxin (Cardiac Glycoside).
Digoxin has 2 major-labeled pairs vs Spironolactone's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 14 minor · 23 total
- Other minor peers for Spironolactone
- Cholestyramine
- Amlodipine/Valsartan
- Enalapril
- Felodipine
2 major · 13 moderate · 105 minor · 120 total
- Other minor peers for Digoxin
- Metformin
- Omeprazole
- Ibuprofen
- Diclofenac
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.