Spironolactone and Amlodipine/Valsartan Interaction
Drug interaction information between Spironolactone and Amlodipine/Valsartan.
Spironolactone and Amlodipine/Valsartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Spironolactone and Amlodipine/Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can cause potassium to build up in your blood. Having too much potassium can be hard on your kidneys and heart.
FDA Label Information
Valsartan Agents Increasing Serum Potassium: Concomitant use of valsartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine.
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
Frequently Asked Questions
What SPL severity band is on file for Spironolactone + Amlodipine/Valsartan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Amlodipine/Valsartan's 14. In the minor band specifically: Spironolactone has 14 (also Digoxin, Cholestyramine, Enalapril, Felodipine); Amlodipine/Valsartan has 10 (also Amlodipine, Hydrochlorothiazide, Valsartan, Sildenafil).
What mechanism field is on file for Spironolactone and Amlodipine/Valsartan?
Both of these medicines can cause potassium to build up in your blood. Having too much potassium can be hard on your kidneys and heart.
Amlodipine/Valsartan carries more major-labeled pairs than Spironolactone
SPL source-record counts only. This page's band is minor · classes on file: Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist); Amlodipine/Valsartan (CCB / ARB Combination).
Amlodipine/Valsartan has 2 major-labeled pairs vs Spironolactone's 0. This page itself is in the minor band, not the major band.
0 major · 9 moderate · 14 minor · 23 total
- Other minor peers for Spironolactone
- Digoxin
- Cholestyramine
- Enalapril
- Felodipine
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Amlodipine/Valsartan
- Amlodipine
- Hydrochlorothiazide
- Valsartan
- Sildenafil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.