Spironolactone and Heparin Interaction
Drug interaction information between Spironolactone and Heparin.
Spironolactone and Heparin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Spironolactone and Heparin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can raise the amount of potassium in your blood. Using them at the same time makes it more likely that your potassium levels will become too high.
FDA Label Information
Examples of drugs that can increase potassium include: ACE inhibitors angiotensin receptor blockers non-steroidal anti-inflammatory drugs (NSAIDs) heparin and low molecular weight heparin trimethoprim 7.2 Lithium Like other diuretics, spironolactone reduces the renal clearance of lithium, thus increasing the risk of lithium toxicity.
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
- Lovastatin moderate
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Hydroxychloroquine moderate
- Indomethacin moderate
- Dipyridamole moderate
Frequently Asked Questions
What SPL severity band is on file for Spironolactone + Heparin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Spironolactone has 23 labeled pairs on file vs Heparin's 20. In the moderate band specifically: Spironolactone has 9 (also Lithium, Trimethoprim, Amlodipine/Benazepril, Benazepril); Heparin has 10 (also Ibuprofen, Celecoxib, Hydroxychloroquine, Indomethacin).
What mechanism field is on file for Spironolactone and Heparin?
Both drugs can raise the amount of potassium in your blood. Using them at the same time makes it more likely that your potassium levels will become too high.
Spironolactone's labeled portfolio outnumbers Heparin
SPL source-record counts only. This page's band is moderate · classes on file: Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist); Heparin (Unfractionated Heparin).
0 major · 9 moderate · 14 minor · 23 total
- Other moderate peers for Spironolactone
- Lithium
- Trimethoprim
- Amlodipine/Benazepril
- Benazepril
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Celecoxib
- Hydroxychloroquine
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.