Spironolactone and Cholestyramine Interaction
Drug interaction information between Spironolactone and Cholestyramine.
Spironolactone and Cholestyramine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Spironolactone and Cholestyramine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs together can cause a dangerous buildup of potassium and acid in your blood.
FDA Label Information
Cholestyramine: Hyperkalemic metabolic acidosis has been reported with concomitant use ( 7.5 ). 7.5 Cholestyramine Hyperkalemic metabolic acidosis has been reported in patients given spironolactone concurrently with cholestyramine.
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Cholestyramine Also Interacts With
- Naproxen moderate
- Olmesartan moderate
- Raloxifene moderate
- Propranolol minor
- Warfarin minor
Frequently Asked Questions
What SPL severity band is on file for Spironolactone + Cholestyramine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Cholestyramine has 34 labeled pairs on file vs Spironolactone's 23. In the minor band specifically: Spironolactone has 14 (also Digoxin, Amlodipine/Valsartan, Enalapril, Felodipine); Cholestyramine has 31 (also Propranolol, Warfarin, Tetracycline, Phenobarbital).
What mechanism field is on file for Spironolactone and Cholestyramine?
Taking these two drugs together can cause a dangerous buildup of potassium and acid in your blood.
Cholestyramine's labeled portfolio outnumbers Spironolactone
SPL source-record counts only. This page's band is minor · classes on file: Spironolactone (Potassium-Sparing Diuretic / Aldosterone Antagonist); Cholestyramine (Bile Acid Sequestrant).
0 major · 9 moderate · 14 minor · 23 total
- Other minor peers for Spironolactone
- Digoxin
- Amlodipine/Valsartan
- Enalapril
- Felodipine
0 major · 3 moderate · 31 minor · 34 total
- Other minor peers for Cholestyramine
- Propranolol
- Warfarin
- Tetracycline
- Phenobarbital
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.