What the FDA labels say about taking them together
Abiraterone and spironolactone
Spironolactone's FDA label of November 28, 2025 names abiraterone in its drug interactions section; the abiraterone labels PlainMeds reads (2) do not name spironolactone. The spironolactone label: “Spironolactone binds to the androgen receptor and may increase prostate-specific antigen (PSA) levels in abiraterone-treated prostate cancer patients. Concomitant use of spironolactone and abiraterone is not recommended.”
Check it at the source: the abiraterone FDA label on DailyMed (effective March 28, 2025, Janssen Biotech, Inc.); the spironolactone FDA label on DailyMed (effective November 28, 2025, Pfizer Laboratories Div Pfizer Inc).
What does the abiraterone label say about spironolactone?
Abiraterone's label (effective March 28, 2025) and its 1 other brand-application label do not name spironolactone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zytiga), Janssen Biotech, Inc., effective March 28, 2025 (SPL set 4e338e89-3cf2-48eb-b6e2-a06c608c6513), via openFDA; the full label on DailyMed
What does the spironolactone label say about abiraterone?
Spironolactone label, drug interactionsSpironolactone binds to the androgen receptor and may increase prostate-specific antigen (PSA) levels in abiraterone-treated prostate cancer patients. Concomitant use of spironolactone and abiraterone is not recommended.
Source: FDA drug label (Aldactone), Pfizer Laboratories Div Pfizer Inc, effective November 28, 2025 (SPL set 0fed2822-3a03-4b64-9857-c682fcd462bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abiraterone | Spironolactone | |
|---|---|---|
| Labeled for | Prostate cancer | Heart failure, Edema (fluid retention), High blood pressure |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.774 per tablet 250 mg tablet | $0.0426 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once