Spironolactone and Abiraterone Interaction
Drug interaction information between Spironolactone and Abiraterone.
Spironolactone and Abiraterone have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Spironolactone and Abiraterone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Spironolactone can interfere with the way abiraterone works against prostate cancer and may cause certain lab tests to show higher cancer markers. This makes it difficult for your doctor to track your progress.
FDA Label Information
• Abiraterone: May increase prostate-specific antigen (PSA) levels ( 7.7 ). 7.7 Abiraterone Spironolactone binds to the androgen receptor and may increase prostate-specific antigen (PSA) levels in abiraterone-treated prostate cancer patients. Concomitant use of spironolactone and abiraterone is not recommended.
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Heparin moderate
- Spironolactone minor
- Digoxin minor
Abiraterone Also Interacts With
- Thioridazine moderate
- Prednisone minor
- Pioglitazone minor
- Ketoconazole minor
- Rifampin minor
Frequently Asked Questions
What SPL severity band is on file for Spironolactone (Acne) + Abiraterone?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
How many labeled pairs sit in each drug's moderate band?
Spironolactone and Abiraterone tie at 7 labeled pairs each. moderate-band counts: Spironolactone 4 alongside Lithium, Trimethoprim, Heparin; Abiraterone 2 alongside Thioridazine.
What mechanism field is on file for Spironolactone (Acne) and Abiraterone?
Spironolactone can interfere with the way abiraterone works against prostate cancer and may cause certain lab tests to show higher cancer markers. This makes it difficult for your doctor to track your progress.
Spironolactone and Abiraterone · moderate-band peers
SPL source-record counts only. This page's band is moderate · classes on file: Spironolactone (Anti-Androgen); Abiraterone (CYP17 Inhibitor).
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Spironolactone
- Lithium
- Trimethoprim
- Heparin
0 major · 2 moderate · 5 minor · 7 total
- Other moderate peers for Abiraterone
- Thioridazine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.