What the FDA labels say about taking them together
Lithium and spironolactone
Spironolactone's FDA label of November 28, 2025 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name spironolactone. The spironolactone label: “Increased risk of lithium toxicity.”
Check it at the source: the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA); the spironolactone FDA label on DailyMed (effective November 28, 2025, Pfizer Laboratories Div Pfizer Inc).
What does the lithium label say about spironolactone?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name spironolactone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
What does the spironolactone label say about lithium?
Spironolactone label, drug interactionsIncreased risk of lithium toxicity ( 7.2 ).
Spironolactone label (Atlantic Biologicals Corp., August 28, 2026), drug interactionsDRUG INTERACTIONS Agents increasing serum potassium: Concomitant administration can lead to hyperkalemia ( 5.1 , 7.1 ) Lithium:
Source: FDA drug label (Spironolactone, NDA209478), Atlantic Biologicals Corp., effective August 28, 2026 (SPL set 5a203ae4-0ed1-0099-e063-6294a90abc85), via openFDA
Source: FDA drug label (Aldactone), Pfizer Laboratories Div Pfizer Inc, effective November 28, 2025 (SPL set 0fed2822-3a03-4b64-9857-c682fcd462bc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lithium | Spironolactone | |
|---|---|---|
| Labeled for | Bipolar disorder | Heart failure, Edema (fluid retention), High blood pressure |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.104 per capsule 300 mg capsule | $0.0426 per tablet 25 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once