Spironolactone and Heparin Interaction
Drug interaction information between Spironolactone and Heparin.
Spironolactone and Heparin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Spironolactone and Heparin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines can cause the amount of potassium in your blood to rise to unsafe levels. This happens because both drugs change how your body manages this mineral.
FDA Label Information
Examples of drugs that can increase potassium include: • ACE inhibitors • angiotensin receptor blockers • non-steroidal anti-inflammatory drugs (NSAIDs) • heparin and low molecular weight heparin • trimethoprim 7.2 Lithium Like other diuretics, ALDACTONE reduces the renal clearance of lithium, thus increasing the risk of lithium toxicity.
Spironolactone Also Interacts With
- Lithium moderate
- Trimethoprim moderate
- Abiraterone moderate
- Spironolactone minor
- Digoxin minor
Heparin Also Interacts With
- Ibuprofen moderate
- Celecoxib moderate
- Hydroxychloroquine moderate
- Indomethacin moderate
- Dipyridamole moderate
Frequently Asked Questions
What SPL severity band is on file for Spironolactone (Acne) + Heparin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Heparin has 20 labeled pairs on file vs Spironolactone's 7. In the moderate band specifically: Spironolactone has 4 (also Lithium, Trimethoprim, Abiraterone); Heparin has 10 (also Ibuprofen, Celecoxib, Hydroxychloroquine, Indomethacin).
What mechanism field is on file for Spironolactone (Acne) and Heparin?
Both of these medicines can cause the amount of potassium in your blood to rise to unsafe levels. This happens because both drugs change how your body manages this mineral.
Heparin's labeled portfolio outnumbers Spironolactone
SPL source-record counts only. This page's band is moderate · classes on file: Spironolactone (Anti-Androgen); Heparin (Unfractionated Heparin).
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Spironolactone
- Lithium
- Trimethoprim
- Abiraterone
0 major · 10 moderate · 10 minor · 20 total
- Other moderate peers for Heparin
- Ibuprofen
- Celecoxib
- Hydroxychloroquine
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.