Digoxin and Epinephrine Interaction
Drug interaction information between Digoxin and Epinephrine.
Digoxin and Epinephrine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Digoxin and Epinephrine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs affect how the heart beats, and taking them together can cause the heart to develop dangerous, irregular rhythms.
FDA Label Information
Sympathomimetics Epinephrine Norepinephrine Dopamine Can increase the risk of cardiac arrhythmias Neuromuscular Blocking Agents Succinylcholine May cause sudden extrusion of potassium from muscle cells causing arrhythmias in patients taking digoxin.
Digoxin Also Interacts With
- Nicardipine major
- Posaconazole major
- Sotalol moderate
- Dofetilide moderate
- Ivabradine moderate
Epinephrine Also Interacts With
- Tranylcypromine major
- Carbidopa/Levodopa moderate
- Imipramine moderate
- Levothyroxine minor
- Clonidine minor
Frequently Asked Questions
What SPL severity band is on file for Digoxin + Epinephrine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Digoxin has 120 labeled pairs on file vs Epinephrine's 28. In the moderate band specifically: Digoxin has 13 (also Sotalol, Dofetilide, Ivabradine, Dopamine); Epinephrine has 3 (also Carbidopa/Levodopa, Imipramine).
What mechanism field is on file for Digoxin and Epinephrine?
Both drugs affect how the heart beats, and taking them together can cause the heart to develop dangerous, irregular rhythms.
Digoxin carries more major-labeled pairs than Epinephrine
SPL source-record counts only. This page's band is moderate · classes on file: Digoxin (Cardiac Glycoside); Epinephrine (Adrenergic Agonist).
Digoxin has 2 major-labeled pairs vs Epinephrine's 1. This page itself is in the moderate band, not the major band.
2 major · 13 moderate · 105 minor · 120 total
- Other moderate peers for Digoxin
- Sotalol
- Dofetilide
- Ivabradine
- Dopamine
1 major · 3 moderate · 24 minor · 28 total
- Other moderate peers for Epinephrine
- Carbidopa/Levodopa
- Imipramine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.