What the FDA labels say about taking them together
Digoxin and epinephrine
Digoxin's FDA label of December 5, 2024 names epinephrine in its drug interactions section; the epinephrine labels PlainMeds reads (4) do not name digoxin. The digoxin label: “Sympathomimetics Epinephrine Can increase the risk of cardiac arrhythmias.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the epinephrine FDA label on DailyMed (effective July 13, 2026, A-S Medication Solutions).
What does the digoxin label say about epinephrine?
Digoxin label, drug interactionsSympathomimetics; Epinephrine Norepinephrine Dopamine; Can increase the risk of cardiac arrhythmias
Source: FDA drug label (Digoxin, NDA021648), Hikma Pharmaceuticals USA Inc., effective April 10, 2025 (SPL set 1b7e5c6e-e052-41b0-a4ce-05dfe62faaaf), via openFDA
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the epinephrine label say about digoxin?
Epinephrine's label (effective July 13, 2026) and its 3 other brand-application labels do not name digoxin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Epinephrine), A-S Medication Solutions, effective July 13, 2026 (SPL set 6e811e28-0199-4df7-a916-5940c632401d), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Epinephrine | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $123.51 per unit 0.15 mg auto-injct |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once