Sildenafil and Amlodipine Interaction
Drug interaction information between Sildenafil and Amlodipine.
Sildenafil and Amlodipine have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sildenafil and Amlodipine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs can lower your blood pressure, and taking them together might cause your blood pressure to drop too low.
FDA Label Information
Sildenafil Monitor for hypotension when sildenafil is co-administered with amlodipine [see CLINICAL PHARMACOLOGY ( 12.2 )] .
Sildenafil Also Interacts With
- Ketoconazole major
- Erythromycin major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
Amlodipine Also Interacts With
- Simvastatin major
- Amlodipine/Benazepril major
- Ezetimibe major
- Ezetimibe/Simvastatin major
- Nirmatrelvir/Ritonavir moderate
Frequently Asked Questions
What SPL severity band is on file for Sildenafil + Amlodipine?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amlodipine has 15 labeled pairs on file vs Sildenafil's 10. In the minor band specifically: Sildenafil has 3 (also Amlodipine/Valsartan, Nitroglycerin); Amlodipine has 10 (also Cyclosporine, Amlodipine/Valsartan, Clarithromycin, Darunavir).
What mechanism field is on file for Sildenafil and Amlodipine?
Both drugs can lower your blood pressure, and taking them together might cause your blood pressure to drop too low.
Sildenafil carries more major-labeled pairs than Amlodipine
SPL source-record counts only. This page's band is minor · classes on file: Sildenafil (PDE5 Inhibitor); Amlodipine (Calcium Channel Blocker).
Sildenafil has 6 major-labeled pairs vs Amlodipine's 4. This page itself is in the minor band, not the major band.
6 major · 1 moderate · 3 minor · 10 total
- Other minor peers for Sildenafil
- Amlodipine/Valsartan
- Nitroglycerin
4 major · 1 moderate · 10 minor · 15 total
- Other minor peers for Amlodipine
- Cyclosporine
- Amlodipine/Valsartan
- Clarithromycin
- Darunavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.