What the FDA labels say about taking them together
Itraconazole and sildenafil
Itraconazole's FDA label of July 13, 2026 names sildenafil in its drug interactions section, and sildenafil's label names itraconazole too. The sildenafil label: “CYP3A4 inhibitors: Increase VIAGRA exposure ▪ Ritonavir:”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the sildenafil FDA label on DailyMed (effective November 17, 2023, Viatris Specialty LLC).
What does the itraconazole label say about sildenafil?
Itraconazole label, drug interactionsAliskiren Riociguat Sildenafil (for pulmonary hypertension) Tadalafil (for pulmonary hypertension) Not recommended during and 2 weeks after SPORANOX ® treatment.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the sildenafil label say about itraconazole?
Sildenafil label, drug interactionsCYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, erythromycin): Increase VIAGRA exposure ( 2.4 , 7.4 , 12.3 ) ▪ Ritonavir:
Vybrique label (IBSA Pharma Inc., July 8, 2026), drug interactionsDRUG INTERACTIONS VYBRIQUE can potentiate the hypotensive effects of nitrates, alpha blockers, and antihypertensives. ( 4.1 , 5.5 , 7.1 , 7.2 , 7.3 , 12.2 ) With concomitant use of alpha blockers, initiate VYBRIQUE at 25 mg dose. ( 2.2 ) CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, erythromycin) increase VYBRIQUE exposure.
Source: FDA drug label (Vybrique, NDA210858), IBSA Pharma Inc., effective July 8, 2026 (SPL set 9213fec1-e0c0-4ef7-9718-d97922a3f4d8), via openFDA
Source: FDA drug label (Viagra), Viatris Specialty LLC, effective November 17, 2023 (SPL set d905dc8d-917f-4ea3-a4ee-a1ecf6967d4e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Sildenafil | |
|---|---|---|
| Labeled for | Fungal infections | Erectile dysfunction, Pulmonary arterial hypertension |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.132 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once