Sildenafil and Nitroglycerin Interaction
Drug interaction information between Sildenafil and Nitroglycerin.
Sildenafil and Nitroglycerin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sildenafil and Nitroglycerin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these drugs work to relax and widen your blood vessels. Taking them together can cause your blood pressure to drop to a dangerously low level.
FDA Label Information
PDE-5-Inhibitors such as avanafil, sildenafil, vardenafil, and tadalafil have been shown to potentiate the hypotensive effects of organic nitrates.
Sildenafil Also Interacts With
- Ketoconazole major
- Erythromycin major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
Nitroglycerin Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Aspirin minor
- Tadalafil minor
- Heparin minor
Frequently Asked Questions
What SPL severity band is on file for Sildenafil + Nitroglycerin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Sildenafil has 10 labeled pairs on file vs Nitroglycerin's 8. In the minor band specifically: Sildenafil has 3 (also Amlodipine, Amlodipine/Valsartan); Nitroglycerin has 6 (also Aspirin, Tadalafil, Heparin, Isradipine).
What mechanism field is on file for Sildenafil and Nitroglycerin?
Both of these drugs work to relax and widen your blood vessels. Taking them together can cause your blood pressure to drop to a dangerously low level.
Sildenafil carries more major-labeled pairs than Nitroglycerin
SPL source-record counts only. This page's band is minor · classes on file: Sildenafil (PDE5 Inhibitor); Nitroglycerin (Nitrate Vasodilator).
Sildenafil has 6 major-labeled pairs vs Nitroglycerin's 0. This page itself is in the minor band, not the major band.
6 major · 1 moderate · 3 minor · 10 total
- Other minor peers for Sildenafil
- Amlodipine
- Amlodipine/Valsartan
0 major · 2 moderate · 6 minor · 8 total
- Other minor peers for Nitroglycerin
- Aspirin
- Tadalafil
- Heparin
- Isradipine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.