Sildenafil and Amlodipine/Valsartan Interaction
Drug interaction information between Sildenafil and Amlodipine/Valsartan.
Sildenafil and Amlodipine/Valsartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Sildenafil and Amlodipine/Valsartan. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both of these medicines lower blood pressure, and taking them together can cause your blood pressure to drop too low.
FDA Label Information
Sildenafil Monitor for hypotension when sildenafil is coadministered with amlodipine [see Clinical Pharmacology (12.2)].
Sildenafil Also Interacts With
- Ketoconazole major
- Erythromycin major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
Frequently Asked Questions
What SPL severity band is on file for Sildenafil + Amlodipine/Valsartan?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amlodipine/Valsartan has 14 labeled pairs on file vs Sildenafil's 10. In the minor band specifically: Sildenafil has 3 (also Amlodipine, Nitroglycerin); Amlodipine/Valsartan has 10 (also Amlodipine, Hydrochlorothiazide, Spironolactone, Valsartan).
What mechanism field is on file for Sildenafil and Amlodipine/Valsartan?
Both of these medicines lower blood pressure, and taking them together can cause your blood pressure to drop too low.
Sildenafil carries more major-labeled pairs than Amlodipine/Valsartan
SPL source-record counts only. This page's band is minor · classes on file: Sildenafil (PDE5 Inhibitor); Amlodipine/Valsartan (CCB / ARB Combination).
Sildenafil has 6 major-labeled pairs vs Amlodipine/Valsartan's 2. This page itself is in the minor band, not the major band.
6 major · 1 moderate · 3 minor · 10 total
- Other minor peers for Sildenafil
- Amlodipine
- Nitroglycerin
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Amlodipine/Valsartan
- Amlodipine
- Hydrochlorothiazide
- Spironolactone
- Valsartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.