Sildenafil and Erythromycin Interaction
Drug interaction information between Sildenafil and Erythromycin.
Sildenafil and Erythromycin have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Sildenafil and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin prevents your body from processing sildenafil normally, which increases the amount of medicine in your blood.
FDA Label Information
7 DRUG INTERACTIONS Sildenafil can potentiate the hypotensive effects of nitrates, alpha blockers, and anti-hypertensives ( 4.1 , 5.5 , 7.1 , 7.2 , 7.3 , 12.2 ) With concomitant use of alpha blockers, initiate sildenafil at 25 mg dose ( 2.3 ) CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, erythromycin): Increase sildenafil exposure ( 2.4 , 7.4 , 12.3 ) Ritonavir: Do not exceed a maximum single dose of 25 mg in a 48 hour period ( 2.4 , 5.6 ) Erythromycin or strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, saquinavir): Consider a starting dose of 25 mg ( 2.4 , 7.4...
Sildenafil Also Interacts With
- Ketoconazole major
- Itraconazole major
- Darunavir major
- Hydralazine/Isosorbide Dinitrate major
- Nirmatrelvir/Ritonavir major
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Lefamulin moderate
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Sildenafil + Erythromycin?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Sildenafil's 10. In the major band specifically: Sildenafil has 6 (also Ketoconazole, Itraconazole, Darunavir, Hydralazine); Erythromycin has 4 (also Eplerenone, Pitavastatin, Risperidone).
What mechanism field is on file for Sildenafil and Erythromycin?
Erythromycin prevents your body from processing sildenafil normally, which increases the amount of medicine in your blood.
Sildenafil carries more major-labeled pairs than Erythromycin
SPL source-record counts only. This page's band is major · classes on file: Sildenafil (PDE5 Inhibitor); Erythromycin (Macrolide Antibiotic).
Sildenafil has 6 major-labeled pairs vs Erythromycin's 4.
6 major · 1 moderate · 3 minor · 10 total
- Other major peers for Sildenafil
- Ketoconazole
- Itraconazole
- Darunavir
- Hydralazine
4 major · 6 moderate · 53 minor · 63 total
- Other major peers for Erythromycin
- Eplerenone
- Pitavastatin
- Risperidone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.